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Correlation of antifungal susceptibility and sequence types within Cryptococcus neoformans VNI from HIV patients, and ERG11 gene polymorphism.
J Mycol Med
November 2023
Department of Clinical Microbiology, National Reference Center for Mycosis, Center for Interdisciplinary Research on Medicines, University of Liege, Liege, Belgium.
Introduction: Here we tested the correlation between minimum inhibitory concentrations (MICs) of major antifungal agents and sequence types (STs) within Cryptococcus neoformans VNI isolates, and explored the ERG11 gene of included strains.
Materials And Methods: We analysed 23 C. neoformans strains categorised into two groups according to the distribution of the ST profile in Kinshasa clinics (Democratic Republic of Congo): major ST [ST93 (n = 15)], and less common STs [ST659 (n = 2), ST5 (n = 2), ST4 (n = 1), ST 53 (n = 1), ST31 (n = 1), and ST69 (n = 1)].
The silent flucytosine shortage in Europe - not a distant problem.
Lancet Reg Health Eur
July 2023
Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Mutations and/or Overexpressions of ERG4 and ERG11 Genes in Clinical Azoles-Resistant Isolates of Candida albicans.
Microb Drug Resist
July 2017
Department of Dermatovenereology, The Second Hospital of Shanxi Medical University, Taiyuan City, Shanxi Province, China .
Article Synopsis
- The study aimed to explore if mutations or overexpression of the ERG4 and ERG11 genes contribute to drug resistance against azoles in Candida albicans.
- Out of 34 clinical isolates tested, significant percentages showed resistance to fluconazole, itraconazole, and voriconazole, with mutations found primarily in the ERG11 gene.
- Results indicated that resistance is linked to mutations in ERG11, while both ERG4 and ERG11 are overexpressed in resistant strains, suggesting that their expression may not be connected in resistant isolates.
Exploiting cis-acting replication elements to direct hepatitis C virus-dependent transgene expression.
J Virol
May 2005
Research & Development Center, FUSO Pharmaceutical Industries, LTD., 2-3-30 Morinomiya, Joto-ku, Osaka 536-8523, Japan.
We describe here a novel targeting gene therapy strategy to direct gene expression responsive to hepatitis C virus (HCV). The goal was approached by engineering a construct containing the antisense sequence of the transgene and internal ribosome entry site of encephalomyocarditis virus flanked by 5'- and 3'-end sequences of HCV cDNA that contain cis-acting replication elements. Thus, expression of the transgene is only promoted when the minus-strand RNA has been synthesized by the functional replication machinery present in infected cells.
View Article and Find Full Text PDFA placebo-controlled trial of maintenance therapy with fluconazole after treatment of cryptococcal meningitis in the acquired immunodeficiency syndrome. California Collaborative Treatment Group.
N Engl J Med
February 1991
Division of Infectious Diseases, Univeristy of California, San Diego.
Background And Methods: In patients with the acquired immunodeficiency syndrome (AIDS), the rate of relapse after primary treatment for cryptococcal meningitis remains high. We conducted a controlled, double-blind trial to evaluate the efficacy of maintenance therapy with fluconazole. At entry into the study, all participants had sterile cultures of cerebrospinal fluid, blood, and urine after following a standardized course of therapy for culture-proved cryptococcal meningitis.
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