Bevel-tip needles are commonly utilized in percutaneous medical interventions where a curved insertion trajectory is required. To avoid deviation from the intended trajectory, needle shape sensing and tip localization is crucial in providing the operator with feedback. There is an abundance of previous work that investigate the medical application of fiber Bragg grating (FBG) sensors, but most works select only one specific type of fiber among the many available sensor options to integrate into their hardware designs. In this work, we compare two different types of FBG sensors under identical conditions and application, namely, acting as the sensor for needle insertion shape reconstruction. We built a three-channel single core needle and a seven-channel multicore fiber (MCF) needle and discuss the pros and cons of both constructions for shape sensing experiments into constant curvature jigs. The overall needle tip error is 1.23 mm for the single core needle and 2.08 mm for the multicore needle.
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http://dx.doi.org/10.1109/ismr57123.2023.10130249 | DOI Listing |
Nordisk Alkohol Nark
January 2025
Department of Social Work, Norwegian University of Science and Technology, Trondheim, Norway.
This research explores patterns of views on substance use among Norwegian adolescent girls aged 16-19 years. By examining the participants' experiences, attitudes and needs, the study seeks to uncover how teenage girls experience the use of substances, how the use impacts their daily lives, and their relationships with peers, family and welfare professionals. To achieve this understanding, we utilised Q methodology to capture the perspectives of 42 Norwegian adolescent girls.
View Article and Find Full Text PDFLab Chip
January 2025
Hacettepe University, Institute of Science, Nanotechnology and Nanomedicine Division, Ankara, Turkey.
Phenylketonuria (PKU) is characterized by an autosomal recessive mutation in the phenylalanine hydroxylase (PAH) gene. Impaired PAH enzyme activity leads to the accumulation of phenylalanine (Phe) and its metabolites in the bloodstream, which disrupts the central nervous system and causes psychomotor retardation. Early diagnosis of PKU is essential for timely intervention.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Food Technology and Nutrition, Lovely Professional University, Phagwara 144411, Punjab, India.
This study investigates the functional and biological activities of a polysaccharide-polyphenolic complex derived from the edible mushroom Agrocybe aegerita. Polyphenols (AMP) were extracted using a modified solvent evaporation technique, and polysaccharides (AMPP) were extracted using enzyme-assisted methods, yielding 8.02 %.
View Article and Find Full Text PDFNat Commun
January 2025
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.
The relative contributions of mutation rate variation, selection, and recombination in shaping genomic variation in bacterial populations remain poorly understood. Here we analyze 3318 Yersinia pestis genomes, spanning nearly a century and including 2336 newly sequenced strains, to shed light on the patterns of genetic diversity and variation distribution at the population level. We identify 45 genomic regions ("hot regions", HRs) that, although comprising a minor fraction of the genome, are hotbeds of genetic variation.
View Article and Find Full Text PDFCurr Biol
December 2024
Université Paris Cité, CNRS, Institut Jacques Monod, 75013 Paris, France; Equipe Labellisée LIGUE Contre le Cancer, 75013 Paris, France. Electronic address:
The regulation of mitotic spindle positioning and orientation is central to the morphogenesis of developing embryos and tissues. In many multicellular contexts, cell geometry has been shown to have a major influence on spindle positioning, with spindles that commonly align along the longest cell shape axis. To date, however, we still lack an understanding of how the nature and amplitude of intracellular forces that position, orient, or hold mitotic spindles depend on cell geometry.
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