AI Article Synopsis

  • The study focuses on identifying biomarkers for uterine cervical cancer (UCC) through the analysis of plasma metabolites, highlighting the importance of early detection and prevention methods in reducing mortality rates.
  • Researchers analyzed plasma samples from 45 UCC patients, finding significant changes in 122 metabolites compared to healthy individuals, including increases in arginine and ceramides and decreases in other key metabolites.
  • The findings indicate that specific metabolite profiles may help differentiate UCC patients from healthy controls and could be valuable for predicting their sensitivity to radiation therapy during treatment.

Article Abstract

Aim: Uterine cervical cancer (UCC) is the fourth most common cancer in women, responsible for more than 300 000 deaths worldwide. Its early detection, by cervical cytology, and prevention, by vaccinating against human papilloma virus, greatly contribute to reducing cervical cancer mortality in women. However, penetration of the effective prevention of UCC in Japan remains low. Plasma metabolome analysis is widely used for biomarker discovery and the identification of cancer-specific metabolic pathways. Here, we aimed to identify predictive biomarkers for the diagnosis and radiation sensitivity of UCC using wide-targeted plasma metabolomics.

Methods: We analyzed 628 metabolites in plasma samples obtained from 45 patients with UCC using ultra-high-performance liquid chromatography with tandem mass spectrometry.

Results: The levels of 47 metabolites were significantly increased and those of 75 metabolites were significantly decreased in patients with UCC relative to healthy controls. Increased levels of arginine and ceramides, and decreased levels of tryptophan, ornithine, glycosylceramides, lysophosphatidylcholine, and phosphatidylcholine were characteristic of patients with UCC. Comparison of metabolite profiles in groups susceptible and non-susceptible to radiation therapy, a treatment for UCC, revealed marked variations in polyunsaturated fatty acid, nucleic acid, and arginine metabolism in the group not susceptible to treatment.

Conclusions: Our findings suggest that the metabolite profile of patients with UCC may be an important indicator for distinguishing these patients from healthy cohorts, and may also be useful for predicting sensitivity to radiotherapy.

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Source
http://dx.doi.org/10.1111/jog.15709DOI Listing

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