AI Article Synopsis
- Non-cancer drugs, particularly calcium channel blockers (CCBs), are being explored for their potential in cancer treatment, particularly in relation to lung cancer.
- This study analyzed the impact of CCBs on treatment efficacy in non-small cell lung cancer patients receiving epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), using patient data from 2009 to 2021.
- Results indicated that the use of CCBs is associated with improved progression-free survival and overall survival in these patients; however, more extensive studies are needed to confirm these findings due to the study's limitations.
Article Abstract
Background: Non-cancer drugs are currently being repurposed for cancer treatment. Mounting evidence highlights the influence of calcium channels on tumorigenesis and progression. Hence, inhibition of calcium signaling may be a promising cancer treatment strategy.
Objective: In this study, we aimed to examine whether calcium channel blockers (CCBs) affect the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in patients with non-small cell lung cancer (NSCLC).
Design: We conducted a retrospective analysis.
Methods: In this study, conducted between January 2009 and June 2021, patients with NSCLC treated with erlotinib, or gefitinib for at least 1 week were enrolled and divided into 2 groups: CCBs-/EGFR-TKIs+ and CCBs+/EGFR-TKIs+, depending on whether they received CCB therapy. Progression-free survival (PFS) and overall survival (OS) were determined as the primary and secondary endpoints, respectively.
Result: : The estimated median PFS and OS for the CCBs-/EGFR-TKIs+group were 7.70 and 12.17 months, respectively, and they were significantly different from those of the CCBs+/EGFR-TKIs+ group (10.43 and 18.07 months, respectively). CCB use was associated with improved PFS (adjusted hazard ratios [HR] 0.77, 95% confidence interval [CI]: 0.61-0.98; = .035) and OS (adjusted HR 0.66, 95% CI: 0.51-0.84; < .001).
Conclusion: Calcium channels have been implicated in cancer pathogenesis. Our findings revealed the potential additive anticancer effects of CCBs when used concomitantly with EGFR-TKIs. However, study limitations, including the retrospective nature and small number of patients, necessitate large-scale prospective studies on the therapeutic potential of CCB as an adjunctive therapy with EGFR-TKIs in patients with NSCLC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262673 | PMC |
| http://dx.doi.org/10.1177/15347354231178903 | DOI Listing |
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