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| http://dx.doi.org/10.1016/S1473-3099(23)00289-X | DOI Listing |
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Single-chain antibody gene therapy strategy based on high-throughput screening triggers sustained antiviral activity in the body.
J Virol
December 2024
College of Animal Science and Technology, Northwest A&F University College of Animal Science and Technology, Yangling, China.
The occurrence of viral diseases poses a huge threat and impact on human public health safety and the development of the animal and fishery industry. Here, a strain of single-chain antibody fragment, scFv-1, was isolated from the phage antibody display library construct by immunizing New Zealand white rabbits with rhabdovirus. analysis showed that the single-chain antibody could inhibit the infection of the virus in multiple pathways, including adsorption, fusion, and release.
View Article and Find Full Text PDFJohn Brooksby was an outstanding Scottish veterinary virologist who worked at the Pirbright Institute (Pirbright) for 40 years, including 16 as the institute's director. He devised quantitative methods for measuring neutralising antibodies and perfected a complement fixation test for the diagnosis, typing and strain differentiation of foot and mouth disease (FMD), especially when combined with neutralisation. He identified four of the seven types of FMD virus (FMDV) and many subtypes.
View Article and Find Full Text PDFAfrican swine fever from Kenya to five continents: the role of wild boar.
Rev Sci Tech
December 2024
African swine fever (ASF) is currently the largest threat to world pork production. The complexity of the virus, its persistence in the environment, the particular immune response it elicits without significant neutralising antibodies, its capacity for transmission by several routes and the presentation of different clinical forms, from acute with high mortality to attenuated to chronic, all pose significant challenges. This article provides an overview of the epidemiological situation of ASF across five continents, the role of wild boar in virus transmission, the development of new immunological tools that aim to enhance protection against this complicated virus in wild boar, and the protection studies that are under way.
View Article and Find Full Text PDFUnlabelled: SARS-CoV-2 mRNA vaccines induce robust and persistent germinal centre (GC) B cell responses in humans. It remains unclear how the continuous evolution of the virus impacts the breadth of the induced GC B cell response. Using ultrasound-guided fine needle aspiration, we examined draining lymph nodes of nine healthy adults following bivalent booster immunization.
View Article and Find Full Text PDFA Novel Circular Delta-XBB15 RBD Dimeric Protein Subunit Vaccine Mediated by Split Intein Elicits an Immune Response and Protection Against Multiple SARS-CoV-2 Variants in Mice.
J Med Virol
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Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
SARS-CoV-2 continues to mutate, leading to breakthrough infections. The development of new vaccine strategies to combat various strains is crucial. Protein cyclization can enhance thermal stability and may improve immunogenicity.
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