AI Article Synopsis
- The study explored how Salacia reticulata (SR) and simvastatin (SVS) affect oxidative stress and insulin resistance in rats on a high-fat diet.
- Results showed that both SR and SVS significantly reduced harmful effects of high-fat diets, like elevated triglycerides and LDL cholesterol, while increasing HDL levels and improving antioxidant enzyme activity.
- SR outperformed SVS, suggesting that these treatments could be a new approach to managing obesity and metabolic disorders.
Article Abstract
Background: The present study investigated the effects of Salacia reticulata and simvastatin on oxidative stress and insulin resistance in Sprague-Dawley (SD) rats. We compared the protective effect of a methanolic extract of Salacia reticulata (SR) with simvastatin (SVS) in rats fed a high-fat diet (HFD).
Methods And Results: Male Sprague-Dawley rats were divided into the following five different groups: control (C), C+SR, HFD, HFD+SR, and HFD+SVS. High-fat diet fed rats showed hyperglycemia, hyperinsulinemia, hyperleptinemia, dyslipidemia, and hypoadiponectinemia after 90 days. Treatment of high-fat diet fed rats with SR/SVS significantly (p < 0.05) reduced high-fat diet induced increases in plasma triglycerides, total cholesterol, very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and decreased high- density lipoprotein (HDL) accompanied by an increase in lipid peroxidation (LPO) and protein oxidation. In addition, a significant decrease in the activities of antioxidant enzymes and enzymes of the polyol pathway was observed in rats fed high-fat diet. SR was found to be more effective than SVS. Moreover, infiltration of inflammatory cells and fibrosis in the liver of high-fat diet fed rats by SR/SVS were also prevented.
Conclusions: The present study confirms that SR/SVS may be a new and promising remedial approach because of its beneficial effects on the pathophysiological processes of obesity and related metabolic disorders.
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| http://dx.doi.org/10.1016/j.biopha.2023.114960 | DOI Listing |
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