COVID-19 restrictions in 2020 reduced traffic worldwide and altered animal movement.
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Integration of clinical, pathological, radiological, and transcriptomic data improves prediction for first-line immunotherapy outcome in metastatic non-small cell lung cancer.
Nat Commun
January 2025
Bioinformatics and computational systems biology of cancer, Institut Curie, Inserm U900, PSL Research University, Paris, France.
Immunotherapy is improving the survival of patients with metastatic non-small cell lung cancer (NSCLC), yet reliable biomarkers are needed to identify responders prospectively and optimize patient care. In this study, we explore the benefits of multimodal approaches to predict immunotherapy outcome using multiple machine learning algorithms and integration strategies. We analyze baseline multimodal data from a cohort of 317 metastatic NSCLC patients treated with first-line immunotherapy, including positron emission tomography images, digitized pathological slides, bulk transcriptomic profiles, and clinical information.
View Article and Find Full Text PDFPrevalence of self-medication among university students diagnosed with temporomandibular disorders.
J Oral Facial Pain Headache
September 2024
Department of Dentistry, School of Health Sciences, University of Brasília (UnB), 70910-900 Brasília, DF, Brazil.
Temporomandibular disorders (TMD) usually affect the stomatognathic system and can be symptomatic. Patients often self-medicate to relieve symptoms, and this can increase the risk of complications such as adverse drug reactions, overdose, physical and psychological dependence, and delay of appropriate treatment. It is important for dentists to know the prevalence of self-medication to investigate this condition in their patients, thus the primary aim of this study was to estimate the prevalence of self-medication among university students with no TMD, non-painful TMD and painful TMD and the secondary aim was to assess association with independent factors.
View Article and Find Full Text PDFThe associations of the diagnostic criterion pain modified by function with functional limitation and behavioral frequency.
J Oral Facial Pain Headache
September 2024
Department of Oral Diagnostic Sciences, University at Buffalo, Buffalo, NY 14214, USA.
The aim is to assess the associations of jaw functional limitation and jaw overuse behavior with pain modified by function as a required diagnostic criterion for painful temporomandibular disorders. This cross-sectional study from the TMJ Impact Project utilized secondary data analyses of 249 participants who met the inclusion criteria of having facial pain in the prior 30 days and valid responses to the pain modified by function (Items 4A-D derived from the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Symptom Questionnaire). Independent -tests (alpha = 0.
View Article and Find Full Text PDFImpact of intermediate-dose tertiary prophylaxis on quality of life and psychological aspects of adult patients with severe/moderate hemophilia A.
Hematology
December 2025
Department of Hematology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu Second Clinical College of Chongqing Medical University, Chengdu, People's Republic of China.
Objectives: Whether intermediate-dose tertiary prophylaxis can improve quality of life and psychological health in adults with severe/moderate hemophilia A has not been determined. This research aims to explore the impact of intermediate-dose tertiary prophylaxis with recombinant human FVIII (rhFVIII) on quality of life, anxiety and depression in such individuals transitioned from on-demand treatment.
Methods: This retrospective analysis collected data from July 2019 to July 2022.
Predictors of Potentially Inappropriate Stimulant Prescribing Among Adults.
Pharmacoepidemiol Drug Saf
January 2025
Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Purpose: Increases in adult stimulant prescribing pose a potential risk due to the higher prevalence of contraindicated conditions among this population. We sought to identify patient, provider, and visit characteristics predictive of potentially inappropriate adult stimulant prescriptions.
Methods: We conducted a repeated cross-sectional study using the National Ambulatory Medical Care Survey, a nationally representative weighted sample of 5 453 702 723 ambulatory care visits from 2012 to 2019.
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