Reversing age-associated taurine loss improves mouse longevity and monkey health.
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Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice.
PLoS One
January 2025
Department of Neuroscience, Laboratory of Prion Neurobiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
There is no cure for Marinesco-Sjögren syndrome (MSS), a genetic multisystem disease linked to loss-of-function mutations in the SIL1 gene, encoding a BiP co-chaperone. Previously, we showed that the PERK kinase inhibitor GSK2606414 delays cerebellar Purkinje cell (PC) degeneration and the onset of ataxia in the woozy mouse model of MSS. However, GSK2606414 is toxic to the pancreas and does not completely rescue the woozy phenotype.
View Article and Find Full Text PDFTranscriptomics study of hippocampus in mice exposed to heat stress.
Psychoneuroendocrinology
January 2025
College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, Jiangsu, China. Electronic address:
Article Synopsis
- Heat stress (HS) prompts neuroinflammation and cognitive issues in the brain, leading to a study that compared the gene expression of mouse hippocampal tissue under HS conditions versus control.
- Analysis showed that HS exposure resulted in 210 differentially expressed genes, indicating significant changes, with 72 genes upregulated and 138 downregulated.
- Notably, the study found that taurine treatment could improve cognitive functions affected by HS, suggesting potential strategies for mitigating heat-induced cognitive impairments in vulnerable groups.
Development and Validation of a Robust and Straightforward LC-MS Method for Measuring Taurine in Whole Blood and Plasma of Dogs and Reference Intervals Calculation.
Animals (Basel)
December 2024
CREA Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy.
Several studies have highlighted the essential role of taurine in maintaining the health of small animals, particularly dogs. Taurine deficiency has been linked to various health issues, especially in certain dog breeds. Therefore, accurately assessing taurine levels in canine blood is crucial for diagnosing and monitoring these conditions.
View Article and Find Full Text PDFIntestinal Foxl1+ cell-derived CXCL12 maintains epithelial homeostasis by modulating cellular metabolism.
Int Immunol
January 2025
Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Several mesenchymal cell populations are known to regulate intestinal stem cell (ISC) self-renewal and differentiation. However, the influences of signaling mediators derived from mesenchymal cells other than ISC niche factors on epithelial homeostasis remain poorly understood. Here, we show that host and microbial metabolites, such as taurine and GABA, act on PDGFRαhigh Foxl1high sub-epithelial mesenchymal cells to regulate their transcription.
View Article and Find Full Text PDFInterplay of serum taurine, S-adenosylmethionine, and cysteine levels in cancer risk: a prospective study.
Front Pharmacol
December 2024
Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Background: Amino acids are known to play critical roles in cancer metabolism and progression. Among them, taurine, S-adenosylmethionine (SAM), and cysteine have garnered particular attention due to their interconnected metabolic pathways. This study sought to explore the associations between serum levels of these amino acids and cancer risk within Chinese adults.
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