Bioassay-guided investigation of the EtOAc-soluble extract of a culture of the marine-derived fungus sp. M16 led to the isolation of seven new polyketide- and terpenoid-derived metabolites (, , -), along with known polyketides (, -). Structures of compounds , , and - were established by analysis of spectroscopic data. Absolute configurations of compounds , , , , , and were determined by the comparison of experimental ECD spectra with calculated CD data. Compound exhibited moderate antiplasmodial activity against both chloroquine-sensitive and -resistant strains of .
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| http://dx.doi.org/10.1021/acs.jnatprod.3c00175 | DOI Listing |
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