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Light-eye-body axis: exploring the network from retinal illumination to systemic regulation.
Theranostics
January 2025
Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P.R. China.
The human body is an intricate system, where diverse and complex signaling among different organs sustains physiological activities. The eye, as a primary organ for information acquisition, not only plays a crucial role in visual perception but also, as increasing evidence suggests, exerts a broad influence on the entire body through complex circuits upon receiving light signals which is called non-image-forming vision. However, the extent and mechanisms of light's impact on the body through the eyes remain insufficiently explored.
View Article and Find Full Text PDFClimate change and epigenetics: Unraveling the role of methylation in response to thermal instability in the Antarctic plant Colobanthus quitensis.
Physiol Plant
January 2025
Centro de Ecología Integrativa (CEI), Instituto de Ciencias Biológicas, Universidad de Talca, Talca, Chile.
Low temperatures are one of the critical conditions affecting the performance and distribution of plants. Exposure to cooling results in the reprogramming of gene expression, which in turn would be mediated by epigenetic regulation. Antarctica is known as one of the most severe ecosystems, but several climate models predict an increase in average temperature, which may positively impact the development of Antarctic plants; however, under warmer temperatures, plants' vulnerability to damages from low-temperature events increases.
View Article and Find Full Text PDFWRKY transcription factors: Hubs for regulating plant growth and stress responses.
J Integr Plant Biol
January 2025
State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan, School of Life Sciences, Yunnan University, Kunming, 650500, China.
As sessile organisms, plants must directly face various stressors. Therefore, plants have evolved a powerful stress resistance system and can adjust their growth and development strategies appropriately in different stressful environments to adapt to complex and ever-changing conditions. Nevertheless, prioritizing defensive responses can hinder growth; this is a crucial factor for plant survival but is detrimental to crop production.
View Article and Find Full Text PDFPatient-driven personal importation in the face of cost barriers to care: can we do better?
Intern Med J
January 2025
Faculty of Medicine, UNSW Sydney, St Vincent's Clinical School, Sydney, New South Wales, Australia.
Australia has a robust public health system that helps to make medicines affordable. However, evidence shows that a significant proportion of Australians still cannot afford medicines prescribed to them and that some patients import medicines from abroad as a result. The strongest predictor of whether patients import medicines is whether they have discussed it with their doctor.
View Article and Find Full Text PDFBiometallic ions and derivatives: a new direction for cancer immunotherapy.
Mol Cancer
January 2025
Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 41001l, China.
Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become a breakthrough in cancer treatment, achieving good efficacy in a wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as immune tolerance and immune escape.
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