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Small intestinal metastasis of cutaneous melanoma in an elderly woman: Survival benefits of surgery and novel targeted therapies - A case report.
Int J Surg Case Rep
January 2025
Visceral Surgery Department II, Mohammed V Military Hospital, Ibn Sina University Hospital, Rabat, Morocco.
Introduction And Importance: Cutaneous malignant melanoma, originating from melanocytes, is a highly metastatic cancer with an incidence rate of 0.9 per 100,000. The gastrointestinal tract is a common site of metastasis, with the small intestine being particularly affected.
View Article and Find Full Text PDFThe influence of simulated worn shoe and foot inversion on heel internal biomechanics during running impact: A subject-specific finite element analysis.
J Biomech
January 2025
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region.
This study explored how systematic changes in running shoe degradation and foot inversion alter the distribution and peak value of heel pressure and calcaneus stress, as well as the total stress-concentration exposure (TSCE) within the calcaneal bone. A foot-shoe finite element model was employed and three shoe wear conditions (new shoe (CON), moderate worn shoe (MWSC), excessive worn shoe (EWSC)) coupled with three foot inversion angles (0°, 10°, 20°) were further modulated. Simulations were conducted at the impact peak instant during running.
View Article and Find Full Text PDFEnhancing Biomechanical Simulations Based on a Posteriori Error Estimates: The Potential of Dual-Weighted Residual-Driven Adaptive Mesh Refinement.
Int J Numer Method Biomed Eng
January 2025
Center of Mathematics, University of the Republic Uruguay, Montevideo, Uruguay.
The finite-element method (FEM) is a well-established procedure for computing approximate solutions to deterministic engineering problems described by partial differential equations. FEM produces discrete approximations of the solution with a discretisation error that can be quantified with a posteriori error estimates. The practical relevance of error estimates for biomechanics problems, especially for soft tissue where the response is governed by large strains, is rarely addressed.
View Article and Find Full Text PDFCircumflex Scapular Artery Perforator Flap and Its Surgical Refinements in Soft Tissue Reconstruction for Various Regions of the Foot and Ankle in Pediatric Patients.
Microsurgery
January 2025
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Introduction: Reconstruction for various regions of the foot and ankle in pediatric patients remains a challenging topic. This study presents the circumflex scapular artery perforator (CSAP) flap and its surgical refinements for addressing soft tissue defects in various regions of the foot and ankle in pediatrics.
Patients And Methods: Forty-seven patients underwent CSAP flap and its surgical refinements for the reconstruction of foot and ankle defects from 2010 to 2022.
Precision Psychobiotics for Gut-Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy.
Microb Biotechnol
January 2025
Fonterra Microbiome Research Centre, University College Cork, Cork, Ireland.
Advancing microbiome-gut-brain axis science requires systematic, rational and translational approaches to bridge the critical knowledge gaps currently preventing full exploitation of the gut microbiome as a tractable therapeutic target for gastrointestinal, mental and brain health. Current research is still marked by many open questions that undermine widespread application to humans. For example, the lack of mechanistic understanding of probiotic effects means it remains unclear why even apparently closely related strains exhibit different effects in vivo.
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