Introduction: Essential Tremor (ET) is one of the most common tremor syndromes typically presented as action tremor, affecting mainly the upper limbs. In at least 30-50% of patients, tremor interferes with quality of life, does not respond to first-line therapies and/or intolerable adverse effects may occur. Therefore, surgery may be considered.
Areas Covered: In this review, the authors discuss and compare unilateral ventral intermedius nucleus deep brain stimulation (VIM DBS) and bilateral DBS with Magnetic Resonance-guided Focused Ultrasound (MRgFUS) thalamotomy, which comprises focused acoustic energy generating ablation under real-time MRI guidance. Discussion includes their impact on tremor reduction and their potential complications. Finally, the authors provide their expert opinion.
Expert Opinion: DBS is adjustable, potentially reversible and allows bilateral treatments; however, it is invasive requires hardware implantation, and has higher surgical risks. Instead, MRgFUS is less invasive, less expensive, and requires no hardware maintenance. Beyond these technical differences, the decision should also involve the patient, family, and caregivers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14737175.2023.2221789 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association Between Common Variants in the / Genes and Risk for Essential Tremor.
Int J Mol Sci
December 2024
Section of Neurology, Hospital Universitario del Sureste, 28500 Arganda del Rey, Spain.
Many clinical, neuroimaging, neuropathological, epidemiological, and genetic data suggest a relationship between essential tremor (ET) and Parkinson's disease (PD). Several hypothesis-based gene association studies attempted to find a genetic association between these diseases. Recent case-control association studies in Chinese and Spanish populations showed a marginal association between the rs1922452 and rs951818 single nucleotide variants (SNVs) and the risk of PD.
View Article and Find Full Text PDFLong-Term Outcomes of Patients with Pre-Existing Essential Tremor After SARS-CoV-2 Infection.
Diagnostics (Basel)
December 2024
Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Background/objectives: Although COVID-19 has been linked to worse outcomes in patients with neurological disorders, its impact on those with essential tremor (ET) remains unclear. To investigate clinical outcomes of ET patients with and without COVID-19 three and a half years post-pandemic.
Methods: 1074 ET patients were evaluated in this retrospective study in the Montefiore Health System from January 2016 to July 2023.
Advancing Parkinson's diagnosis: seed amplification assay for α-synuclein detection in minimally invasive samples.
Mol Cell Biochem
January 2025
Neurodegenerative Diseases Laboratory, Center for Biomedicine, Universidad Mayor, Avenida Alemania 0281, 4780000, Temuco, La Araucanía, Chile.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by tremor, rigidity, and bradykinesia, beginning with early loss of dopaminergic neurons in the ventrolateral substantia nigra and advancing to broader neurodegeneration in the midbrain. The clinical heterogeneity of PD and the lack of specific diagnostic tests present significant challenges, highlighting the need for reliable biomarkers for early diagnosis. Alpha-synuclein (α-Syn), a protein aggregating into Lewy bodies and neurites in PD patients, has emerged as a key biomarker due to its central role in PD pathophysiology and potential to reflect pathological processes.
View Article and Find Full Text PDFSusceptibility map-weighted MRI can distinguish tremor-dominant Parkinson's disease from essential tremor.
Sci Rep
January 2025
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Distinguishing between Parkinson's disease (PD) and essential tremor (ET) can be challenging sometimes. Although positron emission tomography can confirm PD diagnosis, its application is limited by high cost and exposure to radioactive isotopes. Patients with PD exhibit loss of the dorsal nigral hyperintensity on brain magnetic resonance imaging (MRI).
View Article and Find Full Text PDFThe effect of L-dopa and DBS on cortical oscillations in Parkinson's disease analyzed by hidden Markov model algorithm.
Neuroimage
December 2024
Department of Neurosurgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Article Synopsis
- Parkinson's disease (PD) is a movement disorder linked to the degeneration of dopamine-producing neurons, and treatments like Levodopa (L-dopa) and Subthalamic Deep Brain Stimulation (STN-DBS) have distinct effects on brain activity that need further study.
- In a study involving 21 PD patients on L-dopa and 11 patients with STN-DBS, researchers used Magnetoencephalogram (MEG) data to analyze how these treatments impacted brain state dynamics through a statistical method called the Time-delay embedded Hidden Markov Model (TDE-HMM).
- Results showed that L-dopa enhanced motor state and beta wave activity in the brain, correlating
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!