AI Article Synopsis
- This study investigates how steady-state gait in Parkinson's disease patients responds to levodopa, focusing on those with Freezing of Gait (FOG) episodes categorized as OFF-FOG (responsive) and ONOFF-FOG (unresponsive).
- Both OFF-FOG and ONOFF-FOG participants showed improvements in stride-length and stride-velocity when treated with levodopa, although only the OFF-FOG group showed gains in other gait parameters.
- The findings suggest that while levodopa benefits steady-state gait in both groups, carefully managing dosages in ONOFF-FOG individuals is crucial due to their unresponsive FOG episodes, highlighting the need for further research into the underlying causes of these differences.
Article Abstract
Background: In people with Parkinson's disease (PwPD), Freezing of Gait (FOG) episodes can be levodopa responsive (OFF-FOG) or levodopa unresponsive (ONOFF-FOG). Steady-state gait abnormalities, outside of the freezing episodes themselves also exist and the response to levodopa in these different groups has not been previously documented.
Objectives: To define the levodopa responsiveness in steady-state gait in OFF-FOG and ONOFF-FOG individuals.
Methods: Steady-state gait was collected in both the effective levodopa OFF-state (doses withheld > 8 h) and ON-state (1 h after levodopa dosing) in 32 PwPD; 10 with OFF-FOG and 22 with ONOFF-FOG. Levodopa response was compared between the two groups in the mean and variability (CV) of 8 spatiotemporal gait parameters.
Results: Both OFF-FOG and ONOFF-FOG participants showed improvement in mean stride-length and stride-velocity with levodopa. Improvement was seen in the OFF-FOG but not the ONOFF-FOG groups in mean stride-width and CV Integrated pressure with levodopa.
Discussion: In this study we show that steady-state gait deficits improve with levodopa in PwPD with OFF-FOG and ONOFF-FOG, even though episodes of FOG did not resolve in the ONOFF-FOG group. Lowering levodopa in people with ONOFF-FOG, or levodopa-unresponsive freezing of gait, should be undertake with caution and objective gait titration at different levodopa doses may be beneficial. Further work is needed to elucidate the pathophysiologic mechanisms of these differences.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241963 | PMC |
| http://dx.doi.org/10.1016/j.prdoa.2023.100202 | DOI Listing |
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Article Synopsis
- This study investigates how steady-state gait in Parkinson's disease patients responds to levodopa, focusing on those with Freezing of Gait (FOG) episodes categorized as OFF-FOG (responsive) and ONOFF-FOG (unresponsive).
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