AI Article Synopsis

  • The study aimed to evaluate how sociodemographic, clinical, and biological factors affect the long-term cognitive outcomes in patients who survived moderate to severe COVID-19.
  • Researchers assessed 710 adults about 6 to 11 months post-hospital discharge, using a thorough cognitive battery and various evaluations, ultimately looking for links between cognitive impairment and several health markers.
  • Results showed that while a significant number of participants reported cognitive decline, sociodemographic factors were more closely associated with cognitive performance than clinical and inflammatory factors, suggesting these health markers may not be as influential in long-term cognitive deficits after COVID-19.

Article Abstract

Objective: To analyze the potential impact of sociodemographic, clinical and biological factors on the long-term cognitive outcome of patients who survived moderate and severe forms of COVID-19.

Methods: We assessed 710 adult participants (Mean age = 55 ± 14; 48.3% were female) 6 to 11 months after hospital discharge with a complete cognitive battery, as well as a psychiatric, clinical and laboratory evaluation. A large set of inferential statistical methods was used to predict potential variables associated with any long-term cognitive impairment, with a focus on a panel of 28 cytokines and other blood inflammatory and disease severity markers.

Results: Concerning the subjective assessment of cognitive performance, 36.1% reported a slightly poorer overall cognitive performance, and 14.6% reported being severely impacted, compared to their pre-COVID-19 status. Multivariate analysis found sex, age, ethnicity, education, comorbidity, frailty and physical activity associated with general cognition. A bivariate analysis found that G-CSF, IFN-alfa2, IL13, IL15, IL1.RA, EL1.alfa, IL45, IL5, IL6, IL7, TNF-Beta, VEGF, Follow-up C-Reactive Protein, and Follow-up D-Dimer were significantly (p<.05) associated with general cognition. However, a LASSO regression that included all follow-up variables, inflammatory markers and cytokines did not support these findings.

Conclusion: Though we identified several sociodemographic characteristics that might protect against cognitive impairment following SARS-CoV-2 infection, our data do not support a prominent role for clinical status (both during acute and long-stage of COVID-19) or inflammatory background (also during acute and long-stage of COVID-19) to explain the cognitive deficits that can follow COVID-19 infection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242059PMC
http://dx.doi.org/10.3389/fimmu.2023.1174020DOI Listing

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