Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Health Sci Rep
Department of Microbiology, Immunology and Parasitology, College of Health Sciences Addis Ababa University Addis Ababa Ethiopia.
Published: June 2023
Background And Aim: Toxoplasmosis is the most widespread zoonotic disease that affects one-third of the world's population, and imposes a major public health problem worldwide. This study aimed to assess the prevalence of toxoplasmosis among patients with neuropsychiatric patients.
Methods: Electronic databases PubMed, Google Scholar, Web of Science, Research Gate, and Scopus were thoroughly searched from February to March 2022 to identify all relevant studies. The quality of studies was evaluated using the Newcastle-Ottawa quality scale for case-control and cross-sectional studies. Statistical analysis was done using STATA version 12 software. A random effect model was used to compute the global pooled seroprevalence of infection. Heterogeneity was quantified by using value. Subgroup analysis was done, and publication bias was assessed using a funnel plot and Egger's test.
Result: Of 1250 studies, 49 containing 21,093 participants and conducted in 18 countries were included. The global pooled seroprevalence of IgG antibody was 38.27% (95% CI: 32.04-44.9) among neuropsychiatric patients and 25.31% (95% CI: 21.53-29.08) in healthy controls with substantial heterogeneity of 98.3%. The prevalence of IgG antibody was higher in males (17.52%) than in females (12.35%) neuropsychiatric patients. The highest pooled prevalence of IgG antibody was in Europe (57%) followed by Africa (45.25%) and Asia (43%). Time based analysis showed the highest pooled prevalence of IgG antibody in 2012-2016 (41.16%).The global pooled seroprevalence IgM antibody among neuropsychiatric patients and healthy controls was 6.78% (95% CI: 4.87-8.69) and 3.13% (95% CI: 2.02-4.24), respectively.
Conclusion: The pooled prevalence of chronic and acute infection among neuropsychiatric patients was 38.27% and 6.78%, respectively. This showed a high burden of toxoplasmosis among neurological and psychiatric patients and urges routine screening of those patients and providing appropriate treatment. It also indicates the need for different stakeholders to develop targeted prevention and control strategies for infection.
Download full-text PDF |
Source |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242185 | PMC |
http://dx.doi.org/10.1002/hsr2.1319 | DOI Listing |
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