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A novel cystatin in Psoroptes ovis var. cuniculi: molecular characterization, serodiagnostic potential, and its anti-inflammatory property on rabbit peripheral blood mononuclear cells.
Parasit Vectors
September 2024
Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Background: The ectoparasite Psoroptes ovis var. cuniculi causes substantial economic losses to the global rabbit industry. Currently, microscopy for identifying Psoroptes mite in skin scrapings, as the "diagnosis gold standard," remains a challenge owing to its poor sensitivity in detecting low-level and/or early stage mite infestations.
View Article and Find Full Text PDFA Targeted and Protease-Activated Genetically Encoded Melittin-Containing Particle for the Treatment of Cutaneous and Visceral Leishmaniasis.
ACS Appl Mater Interfaces
September 2024
School of Life Sciences and Center of Novel Biomaterials, The Chinese University of Hong Kong, Shatin, Hong Kong SAR 999077, China.
Article Synopsis
- Intracellular infections like leishmaniasis are hard to treat due to pathogens hiding within host cells and developing drug resistance against existing therapies.* -
- Melittin, an antimicrobial peptide, shows effectiveness against leishmaniasis but poses risks to host cells due to its toxic effects, limiting its use in treatments.* -
- A new design strategy creates a therapeutic version of melittin that targets infected cells specifically, improving its effectiveness and safety, and has shown promising results in both cell-based and mouse models.*
A case of NONO::TFE3 cutaneous epithelioid and spindle cell tumor with local recurrence after complete excision.
J Cutan Pathol
December 2024
Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Mesenchymal tumors may display morphologic and immunohistochemical overlap with melanocytic tumors, presenting a pitfall for misdiagnosis. We report a 62-year-old woman who presented with a recurrent dermal and subcutaneous tumor over the Achilles tendon 15 years following complete excision. Both the primary and the recurrent tumors were characterized by nests and sheets of epithelioid and spindle cells with eosinophilic cytoplasm and uniform ovoid nuclei.
View Article and Find Full Text PDFGreen preparation and evaluation of the anti-psoriatic activity of vesicular elastic nanocarriers of kojic acid from Aspergillus oryzae N12: Repurposing of a dermo-cosmetic lead.
Arch Pharm (Weinheim)
November 2024
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt.
Article Synopsis
- Psoriasis is a skin disorder often treated with systemic drugs that can have unwanted side effects; researchers are exploring the use of kojic acid, a fungal metabolite, as a potential topical alternative.
- A bio-friendly vesicular delivery system, made from kojic acid and other agents, was developed, showing effective drug encapsulation and sustained release compared to traditional solutions.
- In vivo studies demonstrated that this new formulation significantly alleviated psoriasis symptoms and was safe for the skin, suggesting that kojic acid could be a beneficial, natural treatment option.
ALK -rearranged Mesenchymal Neoplasms With Prominent Foamy/Pseudolipogenic Cell Morphology : Expanding the Phenotypic Spectrum of ALK Fusion Neoplasms and Report of Novel Fusion Partners.
Am J Surg Pathol
November 2024
Department of Pathology, Faculty of Medicine, Charles University, Plzen, Czech Republic.
The category of ALK -rearranged mesenchymal neoplasms has been evolving rapidly, with reports of morphologically diverse lesions of cutaneous, soft tissue, and visceral origin. While some of these represent morphologically defined entities harboring recurrent ALK fusions (inflammatory myofibroblastic tumor and epithelioid fibrous histiocytoma), others are unclassified by morphology with variable overlap with the tyrosine kinase family of neoplasia and their underlying ALK fusions cannot be suspected based on morphology. We herein report 3 cases that expand the anatomic, morphologic, and genotypic spectrum of ALK -rearranged unclassified neoplasms.
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