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A mixed-methods pilot study of domiciliary nasal high-flow therapy for breathlessness in people with chronic obstructive pulmonary disease who do not qualify for domiciliary long-term oxygen therapy.
Ther Adv Respir Dis
March 2025
Faculty of Medicine and Health Sciences, University of Melbourne, Parkville, VIC, Australia.
Background: High-flow nasal oxygen (HFNO) therapy delivers humidified, heated air with flow rates of up to 60 L/min with oxygen entrained. HFNO has advantages over conventional oxygen therapy, including precise and reliable fraction of inspired oxygen delivery, therefore is recommended as first-line treatment for people with acute hypoxaemic respiratory failure.
Objectives: This pilot study aimed to determine the feasibility and acceptability of domiciliary nasal high flow (NHF) without entrained oxygen for people with chronic obstructive pulmonary disease (COPD) and severe breathlessness.
The Impact of Vitamin-D Supplementation on Individuals with Allergic Rhinitis.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of ENT, School of Medical Sciences and Research, Sharda Hospital, Sharda University, Knowledge Park III, Greater Noida, Uttar Pradesh 201310 India.
Introduction: Allergic rhinitis is a common disease affecting 10 percent people. Sleep, quality of life, and productivity at work are all significantly impacted by severe allergic rhinitis. An increase in allergic diseases has been associated with a lack of vitamin D.
View Article and Find Full Text PDFConservative Management of Macroglossia in Beckwith-Wiedemann Syndrome.
Pediatrics
March 2025
Division of Plastic, Reconstructive, and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Introduction: While severe macroglossia in Beckwith-Wiedemann syndrome (BWS) is often treated with tongue reduction surgery, most patients with mild to moderate macroglossia are nonsurgically managed. Given that outcomes for these conservatively managed patients are not well characterized, this study aims to describe the natural history of patients with macroglossia and BWS who did not undergo early surgery.
Methods: Records of patients with BWS and macroglossia seen between 2004-2024 were reviewed.
Differential effects of high-fat diet on salivary and gut microbiota.
Front Cell Infect Microbiol
March 2025
Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China.
Objectives: Microorganisms contribute to the pathogenesis of obesity, while more studies focus on gut microbiome. However, the relationship between oral microbiota and obesity has yet to be elucidated. This study was designed to investigate the similarities and differences in the effects of a high-fat diet on salivary and gut microbiota through mouse experiments, exploring the hypothesis that oral microbial mechanisms may contribute to obesity.
View Article and Find Full Text PDFUnveiling the geroprotective potential of Monarda didyma L.: insights from in vitro studies and a randomized clinical trial on slowing biological aging and improving quality of life.
Geroscience
March 2025
Department of Cardiac, Thoracic, and Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Aging is driven by fundamental mechanisms like oxidative stress, telomere shortening and changes in DNA methylation, which together prepare the ground for age-related diseases. Botanical extracts, rich in bioactive phytoconstituents, represent a promising resource for developing therapies that target these mechanisms to promote healthy aging. This study explores the geroprotective potential of Monarda didyma L.
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