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Small molecule ATM inhibitors as potential cancer therapy: a patent review (2003-present).
Expert Opin Ther Pat
January 2025
P. Hertsen Moscow Oncology Research Institute, Moscow, Russian Federation.
Introduction: The ataxia telangiectasia mutated kinase (ATM) is key in coordinating the DDR signaling network essential for responding to double-strand breaks (DSBs). Several ATM inhibitors are being investigated for potential anticancer treatment in clinical trials.
Areas Covered: This review aims to provide a comprehensive overview of patents and patent applications since 2003, with a particular focus on the structural properties, activity and efficacy of the claimed ATM kinase small-molecule inhibitors.
Systematic review of economic evaluations of triage tests for women with atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL).
Int J Technol Assess Health Care
November 2024
Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
Article Synopsis
- The study aimed to analyze cost-effectiveness of different triage tests for women with atypical squamous cells (ASC-US) or low-grade lesions (LSIL) compared to repeat cytology.
- A systematic review identified five relevant cost-effectiveness analyses, focusing on tests such as HPV testing and immediate colposcopy, measuring their effectiveness by the detection of cervical intraepithelial neoplasia (CIN2+).
- Findings indicate that HPV testing is often the most cost-effective triage method, while cytology is deemed the least effective despite being less expensive, suggesting a need for updated triage programs for better treatment and resource allocation.
The pattern of reporting and presenting validity evidence of extended matching questions (EMQs) in health professions education: a systematic review.
Med Educ Online
December 2024
Medical Education Department, College of Medicine, Qassim University, Qassim, Saudi Arabia.
The Extended matching Questions (EMQs), or R-type questions, are format of selected-response. The validity evidence for this format is crucial, but there have been reports of misunderstandings about validity. It is unclear what kinds of evidence should be presented and how to present them to support their educational impact.
View Article and Find Full Text PDFQuest for optimal quantum resetting: Protocols for a particle on a chain.
Phys Rev E
September 2024
Department of Physics, Indian Institute of Technology Tirupati, Tirupati 517619, India.
In the classical context, it is well known that, sometimes, if a search does not find its target, it is better to start the process anew. This is known as resetting. The quantum counterpart of resetting also indicates speeding up the detection process by eliminating the dark states, i.
View Article and Find Full Text PDFOptimal Twirling Depth for Classical Shadows in the Presence of Noise.
Phys Rev Lett
September 2024
Physics Department, McGill University, Montréal, Québec H3A 2T8, Canada.
The classical shadows protocol is an efficient strategy for estimating properties of an unknown state ρ using a small number of state copies and measurements. In its original form, it involves twirling the state with unitaries from some ensemble and measuring the twirled state in a fixed basis. It was recently shown that for computing local properties, optimal sample complexity (copies of the state required) is remarkably achieved for unitaries drawn from shallow depth circuits composed of local entangling gates, as opposed to purely local (zero depth) or global twirling (infinite depth) ensembles.
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