Ten undescribed diterpenoids namely rubellawus E-N of structural types pimarane (1, 3-4), nor-abietane (2), nor-pimarane (5-6), isopimarane (7-9), and nor-isopimarane (10), along with eleven known compounds, were isolated and identified from the aerial parts of Callicarpa rubella Lindl. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analyses and quantum chemical computations. Pharmacologically, almost all the compounds exhibited a potential inhibitory effect on oxidized low-density lipoprotein-induced macrophage foam cell formation, which suggests that these compounds may be promising candidates in the treatment of atherosclerosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.phytochem.2023.113748 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phytochemical analysis of different Callicarpa species based on integrating metabolomics and chemometrics.
Phytochem Anal
September 2024
National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Article Synopsis
- Callicarpa species, known for their anti-inflammatory and hemostatic uses, have seen a decline in wild resources, particularly Callicarpa nudiflora, due to extensive medicinal use and management issues.
- The study seeks to find alternative sources for Callicarpa nudiflora and other species, using advanced mass spectrometry techniques to identify and confirm compounds present in these plants.
- Findings suggest that multiple Callicarpa species, like Callicarpa giraldii and Callicarpa longissimi, could serve as substitutes for the widely used Callicarpa nudiflora, addressing concerns around depletion and adulteration.
Diverse diterpenoids from Callicarpa rubella Lindl. as natural inhibitors of macrophage foam cell formation.
Phytochemistry
September 2023
Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, PR China. Electronic address:
Ten undescribed diterpenoids namely rubellawus E-N of structural types pimarane (1, 3-4), nor-abietane (2), nor-pimarane (5-6), isopimarane (7-9), and nor-isopimarane (10), along with eleven known compounds, were isolated and identified from the aerial parts of Callicarpa rubella Lindl. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analyses and quantum chemical computations. Pharmacologically, almost all the compounds exhibited a potential inhibitory effect on oxidized low-density lipoprotein-induced macrophage foam cell formation, which suggests that these compounds may be promising candidates in the treatment of atherosclerosis.
View Article and Find Full Text PDFDiterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux.
Front Pharmacol
January 2023
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research and Development of Natural Products, Yunnan Characteristic Plant Extraction Laboratory, Ministry of Education, School of Pharmacy, Yunnan University, Kunming, China.
Atherosclerosis is the main cause of many cardiovascular diseases and contributes to morbidity and mortality worldwide. The formation of macrophage-derived foam cells plays a critical role in the early stage of atherosclerosis pathogenesis. Diterpenoids found in the flowers of Lindl.
View Article and Find Full Text PDFNew chemical structures and liver-protective activity of the diterpenoids from Callicarpa rubella.
Fitoterapia
March 2023
School of Pharmaceutical Sciences, GuangZhou University of Chinese Medicine, GuangZhou 510006, China.
Callicarpa rubella is a characteristic folk herb in the genus Callicarpa, and has abundant ethnobotanical usage as indigenous medicine in Lingnan area of P. R. China.
View Article and Find Full Text PDFAcetylcholinesterase Inhibitory Activities of Essential Oils from Vietnamese Traditional Medicinal Plants.
Molecules
October 2022
Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA.
Essential oils are promising as environmentally friendly and safe sources of pesticides for human use. Furthermore, they are also of interest as aromatherapeutic agents in the treatment of Alzheimer's disease, and inhibition of the enzyme acetylcholinesterase (AChE) has been evaluated as an important mechanism. The essential oils of some species in the genera , , and of the family Lamiaceae were evaluated for inhibition of electric eel AChE using the Ellman method.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!