A highly regio- and stereoselective hydrochlorination/cyclization of enynes has been reported by FeCl catalysis. A variety of enynes undergo this cyclization transformation with acetic chloride as the chlorine source and HO providing protons via a cationic pathway. This protocol provides a cheap, simple, stereospecific, and effective cyclization to afford heterocyclic alkenyl chloride compounds as isomers with high yields (≤98%) and regioselectivity.
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| http://dx.doi.org/10.1021/acs.orglett.3c01495 | DOI Listing |
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