The positive effect of spermidine in older adults suffering from dementia after 1 year.

Wien Klin Wochenschr

FAZ Floridsdorfer Allergiezentrum, Pius-Parsch-Platz 1/3, 1210, Vienna, Austria.

Published: January 2024

Background: A positive effect of the effect of a 3-month oral spermidine intake on memory performance has already been demonstrated. The continuation of this study aimed to examine whether there could be observed an improvement in memory performance after one year.

Method: 45 residents of the nursing home "Gepflegt Wohnen" in Hart bei Graz, Styria, Austria, were given a daily dose of 3.3 mg spermidine in their diet for one year.

Results: The comparison of the MMSE test results at baseline and after one year demonstrated a significant (p < 0.001) difference. The mean improvement is 5 points.

Conclusion: The new results confirm the already proven positive effect of oral spermidine intake on memory performance.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10776733PMC
http://dx.doi.org/10.1007/s00508-023-02226-zDOI Listing

Publication Analysis

Top Keywords

memory performance
8
positive spermidine
4
spermidine older
4
older adults
4
adults suffering
4
suffering dementia
4
dementia 1 year
4
1 year background
4
background positive
4
positive 3-month
4

Similar Publications

Matched-controlled long-term disease evaluation and neuropsychological outcomes derived from deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson´s disease (PD) are lacking, with inconsistent results regarding the cognitive impact of this procedure. Here we study the long-term effects associated to DBS comparing outcomes with a matched control group. A prospective observational study of 40 patients with PD with bilateral STN-DBS, with a mean follow-up of 9 (6-12) years was conducted.

View Article and Find Full Text PDF

Rationale: Psilocybin shows promise for treating neuropsychiatric disorders. However, insight into its acute effects on cognition is lacking. Given the significant role of executive functions in daily life and treatment efficacy, it is crucial to evaluate how psilocybin influences these cognitive domains.

View Article and Find Full Text PDF

We developed a Metacognitive Offloading Optimization Task (MOOT) whereby participants were instructed to score as many points as possible by accessing words from a presented list either by remembering them (worth 10 points each) or by offloading them (worth less than 10 points each). Results indicated that participants were sensitive to the value of the offloaded items such that when offloaded items carried a high value (e.g.

View Article and Find Full Text PDF

Background: Chronic limb-threatening ischemia (CLTI) in patients with chronic kidney disease (CKD) has a high risk of poor outcomes. We aimed to compare the outcomes of lower extremity revascularization in patients with CLTI stratified by CKD severity in patients enrolled in the prospective, randomized Best Endovascular vs Best Surgical Therapy in Patients with CLTI (BEST-CLI) trial.

Methods: The BEST-CLI trial dataset was queried to categorize patients into three groups according to CKD stage.

View Article and Find Full Text PDF

Robust Mechanically Interlocked Network Ionogels.

Angew Chem Int Ed Engl

January 2025

Shanghai Jiao Tong University, School of Chemistry and Chemical Engineering, 800 Dongchuan Road, 200240, Shanghai, CHINA.

Ionogels have attracted considerable attention as versatile materials due to their unique ionic conductivity and thermal stability. However, relatively weak mechanical performance of many existing ionogels has hindered their broader application. Herein, we develop robust, tough, and impact-resistant mechanically interlocked network ionogels (IGMINs) by incorporating ion liquids with mechanical bonds that can dissipate energy while maintain structural stability.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!