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Dysregulation of hypothalamic-vagal neurocircuits by perinatal high fat diet.
J Physiol
July 2023
Division of Hepato-Gastroenterology, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France.
Perinatal high-fat diet exposure alters oxytocin and corticotropin releasing factor inputs onto vagal neurocircuits controlling gastric motility.
J Physiol
July 2023
Department of Neural and Behavioral Sciences, Pennsylvania State College of Medicine, Hershey, PA, USA.
Perinatal high-fat diet (pHFD) exposure alters the development of vagal neurocircuits that control gastrointestinal (GI) motility and reduce stress resiliency in offspring. Descending oxytocin (OXT; prototypical anti-stress peptide) and corticotropin releasing factor (CRF; prototypical stress peptide) inputs from the paraventricular nucleus (PVN) of the hypothalamus to the dorsal motor nucleus of the vagus (DMV) modulate the GI stress response. How these descending inputs, and their associated changes to GI motility and stress responses, are altered following pHFD exposure are, however, unknown.
View Article and Find Full Text PDFHypothalamic-vagal oxytocinergic neurocircuitry modulates gastric emptying and motility following stress.
J Physiol
November 2020
Department of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA.
Key Points: Stress triggers and exacerbates the symptoms of functional gastrointestinal disorders, such as delayed gastric emptying and impaired gastric motility. Understanding the mechanisms by which the neural circuits, impaired by stress, are restored may help to identify potential targets for more effective therapeutic interventions. Oxytocin administration or release ameliorates the stress-induced delayed gastric emptying and motility.
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