To study the chemical constituents from the stems and leaves of Humulus scandens, this study isolated thirteen compounds by different chromatographic methods including silica gel column, ODS, Sephadex LH-20 and preparative HPLC. Based on comprehensive analysis, the chemical structures were elucidated and identified as citrunohin A(1), chrysosplenetin(2), casticin(3), neoechinulin A(4), ethyl 1H-indole-3-carboxylate(5), 3-hydroxyacetyl-indole(6),(1H-indol-3-yl) oxoacetamide(7), inonotusic acid(8), arteannuin B(9), xanthotoxol(10), α-tocopherol quinone(11), eicosanyl-trans-p-coumarate(12), and 9-oxo-(10E,12E)-octadecadienoic acid(13). Among them, compound 1 was a new dihydrochalcone, and the other compounds were obtained from H. scandens for the first time.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.19540/j.cnki.cjcmm.20221231.201 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[A new dihydrochalcone from Humulus scandens].
Zhongguo Zhong Yao Za Zhi
April 2023
Guangdong Engineering Research Center for Modernization of Traditional Chinese Medicine, Jinan University Guangzhou 510632, China NMPA Key Laboratory for Quality Evaluation of Traditional Chinese Medicine, Jinan University Guangzhou 510632, China.
To study the chemical constituents from the stems and leaves of Humulus scandens, this study isolated thirteen compounds by different chromatographic methods including silica gel column, ODS, Sephadex LH-20 and preparative HPLC. Based on comprehensive analysis, the chemical structures were elucidated and identified as citrunohin A(1), chrysosplenetin(2), casticin(3), neoechinulin A(4), ethyl 1H-indole-3-carboxylate(5), 3-hydroxyacetyl-indole(6),(1H-indol-3-yl) oxoacetamide(7), inonotusic acid(8), arteannuin B(9), xanthotoxol(10), α-tocopherol quinone(11), eicosanyl-trans-p-coumarate(12), and 9-oxo-(10E,12E)-octadecadienoic acid(13). Among them, compound 1 was a new dihydrochalcone, and the other compounds were obtained from H.
View Article and Find Full Text PDFThe Influence of Glycosylation of Natural and Synthetic Prenylated Flavonoids on Binding to Human Serum Albumin and Inhibition of Cyclooxygenases COX-1 and COX-2.
Molecules
July 2017
Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.
Article Synopsis
- Researchers synthesized various prenylated aglycones from xanthohumol, a compound found in hops, using one-step reactions, yielding new flavonoids and glycosides, with four being previously unreported.
- The study looked at how these compounds interact with human serum albumin (HSA) and their ability to inhibit cyclooxygenases (COX-1 and COX-2), important enzymes involved in inflammation.
- Findings revealed that a specific chalcone exhibited the highest binding affinity to HSA and was a more effective inhibitor of cyclooxygenases than other compounds, while adding sugar groups reduced both binding and inhibition efficiency.
Fungal metabolites of xanthohumol with potent antiproliferative activity on human cancer cell lines in vitro.
Bioorg Med Chem
April 2013
Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.
Xanthohumol (1) and xanthohumol D (2) were isolated from spent hops. Isoxanthohumol (3) was obtained from xanthohumol by isomerisation in alkaline solution. Six metabolites were obtained as a result of transformation of xanthohumol (1) by selected fungal cultures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!