Kaixin Powder is a classic prescription for invigorating Qi, nourishing the mind, and calming the mind. It has pharmacological effects of improving learning and memory ability, resisting oxidation, delaying aging, and promoting the differentiation and regeneration of nerve cells. It is mainly used in the modern clinical treatment of amnesia, depression, dementia, and other diseases. The present paper reviewed the research progress on the chemical composition and pharmacological action of Kaixin Powder, predicted and analyzed its quality markers(Q-markers) according to the concept of Chinese medicine Q-markers, including transmission and traceability, specificity, effectiveness, measurability, and compound compatibility environment. The results suggested that sibiricose A5, sibiricose A6, polygalaxanthone Ⅲ, 3',6-disinapoylsucrose, tenuifoliside A, ginsenoside Rg_1, ginsenoside Re, ginsenoside Rb_1, pachymic acid, β-asarone, and α-asarone could be used as Q-markers of Kaixin Powder. This study is expected to provide a scientific basis for establishing the quality control system and the whole process quality traceability system of Kaixin Powder compound preparations.
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| http://dx.doi.org/10.19540/j.cnki.cjcmm.20220919.201 | DOI Listing |
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Analysis of medication rule of Traditional Chinese Medicine in treating depression based on data mining.
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Objective: Depression is a mental disorder characterized by persistent feelings of sadness, decreased interest or pleasure in activities and reduced energy. As a highly prevalent disorder, it seriously endangers the psychosocial functioning of patients. Many scholars have conducted clinical studies on the treatment of depression using different herbal remedies, but there are no studies that integrate these remedies to explore the general medication rule.
View Article and Find Full Text PDF[Mechanism of Kaixin Powder in alleviating breast cancer chemotherapy-induced cognitive impairment by transcriptome association analysis].
Zhongguo Zhong Yao Za Zhi
September 2024
College of Traditional Chinese Medicine, Jinan University Guangzhou 510632, China.
Article Synopsis
- The study investigates the effects of Kaixin Powder (KXP) on behavior and brain tissue in mice undergoing chemotherapy to understand how it may reduce cognitive impairment related to cancer treatment.
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[Research progress on chemical constituents and pharmacological effects of Kaixin Powder and predictive analysis of its Q-markers].
Zhongguo Zhong Yao Za Zhi
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Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Hefei 230012, China Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM) Hefei 230012, China School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center Hefei 230012, China Institute of Pharmaceutics, Anhui Academy of Chinese Medicine Hefei 230012, China.
Kaixin Powder is a classic prescription for invigorating Qi, nourishing the mind, and calming the mind. It has pharmacological effects of improving learning and memory ability, resisting oxidation, delaying aging, and promoting the differentiation and regeneration of nerve cells. It is mainly used in the modern clinical treatment of amnesia, depression, dementia, and other diseases.
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April 2023
Department of Pharmacy, Medical Supplies Center of PLA General Hospital, Chinese PLA General Hospital, Beijing 100853, China.
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Methods: Transcriptome and KEGG pathway analysis were conducted on the hippocampus of depressed rats, then the differentially expressed genes were validated and serum concentration of lipid parameters were identified by enzymatic assays. Furthermore, high-fat diets induced depression-like behaviors in Syrian golden hamsters were conducted to verify the predicted molecular mechanisms acquired from the transcriptome analysis.
[Key quality attributes of benchmark samples of famous classical formula Kaixin Powder].
Zhongguo Zhong Yao Za Zhi
January 2023
School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102400, China.
We prepared 15 batches of Kaixin Powder benchmark samples with the decoction pieces of different batches. Further, we established the specific chromatograms and index component content determination method of Kaixin Powder benchmark samples and analyzed the peaks and similarity of the chromatograms. With sibiricose A5, sibiricose A6, polygalaxanthone Ⅲ, 3,6'-disinapoyl sucrose, ginsenoside Rb_1, β-asarone, α-asarone, and dehydropachymic acid as index components, the index component content determination method was established and 70%-130% of the mean content of each component was set as the range.
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