AI Article Synopsis
- Glechomae Herba, derived from the plant Glechoma longituba, is known for promoting urination, reducing dampness, and alleviating urinary issues, especially effective against kidney stones.
- Recent studies reveal its broad pharmacological benefits, including antibacterial, anti-inflammatory, antioxidant, and anti-tumor properties, contributed by its various chemical compounds like volatile oils and flavonoids.
- The paper identifies potential quality markers (Q-markers) such as ursolic acid and rosmarinic acid, which may help standardize its therapeutic use based on the plant's genetic relations and chemical efficacy.
Article Abstract
Glechomae Herba, the dried aerial part of Glechoma longituba(Labiatae), has the effects of promoting urination, draining dampness, and relieving stranguria. It has received wide attention in recent years owing to the satisfactory efficacy on lithiasis. Amid the in-depth chemical and pharmacological research, it has been found that Glechomae Herba has antibacterial, anti-inflammatory, antioxidant, antithrombotic, hepatoprotective, cholagogic, antitumor, hypoglycemic, and lipid-lowering effects. The main chemical constituents are volatile oils, flavonoids, terpenoids, phenylpropanoids, and organic acids. This paper summarized the chemical constituents and pharmacological effects of Glechomae Herba. Based on genetic relationship of plants, the characteristics, efficacy, and pharmacokinetics of the chemical constituents, and the potential of these constituents as quality markers(Q-markers), it was summed up that ursolic acid, caffeic acid, rosmarinic acid, luteolin-7-O-diglucuronide, apigenin, apigenin-7-O-diglucuronide, apigetrin, and glechone can be the candidate Q-markers of Glechomae Herba.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.19540/j.cnki.cjcmm.20221115.201 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Research progress on chemical constituents and pharmacological effects of Glechomae Herba and prediction of its Q-markers].
Zhongguo Zhong Yao Za Zhi
April 2023
MOE Key Laboratory for Standardization of Chinese Medicines, SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Shanghai R&D Center for Standardization of Chinese Medicines Shanghai 201203, China.
Article Synopsis
- Glechomae Herba, derived from the plant Glechoma longituba, is known for promoting urination, reducing dampness, and alleviating urinary issues, especially effective against kidney stones.
- Recent studies reveal its broad pharmacological benefits, including antibacterial, anti-inflammatory, antioxidant, and anti-tumor properties, contributed by its various chemical compounds like volatile oils and flavonoids.
- The paper identifies potential quality markers (Q-markers) such as ursolic acid and rosmarinic acid, which may help standardize its therapeutic use based on the plant's genetic relations and chemical efficacy.
The phytochemistry, pharmacology and traditional medicinal use of - a systematic review.
RSC Adv
May 2021
Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang University of Chinese Medicine Harbin 150040 China
is a Chinese herb, which has been used in China for thousands of years, mainly for the treatment of nephrolithiasis. This paper summarizes the modern research progress on from the aspects of botany, traditional medicinal use, phytochemistry, pharmacology, pharmacokinetics, analytical methods and quality control. In addition, it also points out the deficiencies of current research on this herb and provides possible directions for its development.
View Article and Find Full Text PDFScreening out key compounds of Glechomae Herba for antiurolithic activity and quality control based on spectrum-effect relationships coupled with UPLC-QDA.
Biomed Pharmacother
May 2022
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, China. Electronic address:
Glechomae Herba (GH) has been widely used in the treatment of urolithiasis, especially kidney stones, in China and Southeast Asia. Pharmacological studies have suggested that the antioxidant property of GH contributes to its anticalculus effect. CaSR is one of the main locations of kidney stones, and the mechanism of action of CaSR inhibitors in the treatment of kidney stones is similar to that of GH.
View Article and Find Full Text PDFChemical composition and anti-complement activity of Glechomae Herba collected in different months.
Biomed Chromatogr
March 2020
The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Jiangxi, Nanchang, China.
Glechomae Herba (GH) is derived from the dried aerial part of Glechoma longituba (Nakai) Kupr., which is harvested from spring to autumn. It has the effects of clearing heat and detoxification.
View Article and Find Full Text PDFCharacterization of the multiple chemical components of Glechomae Herba using ultra high performance liquid chromatography coupled to quadrupole-time-of-flight tandem mass spectrometry with diagnostic ion filtering strategy.
J Sep Sci
April 2019
The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, P. R. China.
Glechomae Herba is a traditional Chinese medicine used for the treatment of urolithiasis, cholelithiasis, and urinary tract infections in China. Identification of chemical constituents is helpful to discover the potential active ingredients. However, this significant work is stymied by complex chemical constituents.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!