Classical domain adaptation methods acquire transferability by regularizing the overall distributional discrepancies between features in the source domain (labeled) and features in the target domain (unlabeled). They often do not differentiate whether the domain differences come from the marginals or the dependence structures. In many business and financial applications, the labeling function usually has different sensitivities to the changes in the marginals versus changes in the dependence structures. Measuring the overall distributional differences will not be discriminative enough in acquiring transferability. Without the needed structural resolution, the learned transfer is less optimal. This article proposes a new domain adaptation approach in which one can measure the differences in the internal dependence structure separately from those in the marginals. By optimizing the relative weights among them, the new regularization strategy greatly relaxes the rigidness of the existing approaches. It allows a learning machine to pay special attention to places where the differences matter the most. Experiments on three real-world datasets show that the improvements are quite notable and robust compared to various benchmark domain adaptation models.
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http://dx.doi.org/10.1109/TNNLS.2023.3279099 | DOI Listing |
Immunol Rev
December 2024
Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
αβT cells protect vertebrates against many diseases, optimizing surveillance using mechanical force to distinguish between pathophysiologic cellular alterations and normal self-constituents. The multi-subunit αβT-cell receptor (TCR) operates outside of thermal equilibrium, harvesting energy via physical forces generated by T-cell motility and actin-myosin machinery. When a peptide-bound major histocompatibility complex molecule (pMHC) on an antigen presenting cell is ligated, the αβTCR on the T cell leverages force to form a catch bond, prolonging bond lifetime, and enhancing antigen discrimination.
View Article and Find Full Text PDFPlant Cell Environ
January 2025
Key Laboratory of the State Forestry and Grassland Administration for the Cultivation of Forests in the Lower Reaches of the Yellow River, College of Forestry, Shandong Agricultural University, Tai'an, China.
How different stress responses by male and female plants are influenced by interactions with rhizosphere microbes remains unclear. In this study, we employed poplar as a dioecious model plant and quantified biotic associations between microorganisms to explore the relationship between microbial associations and plant adaptation. We propose a health index (HI) to comprehensively characterize the physiological characteristics and adaptive capacity of plants under stress.
View Article and Find Full Text PDFThe risk of severe outcomes of influenza increases during pregnancy. Whether vaccine-induced T cell memory-primed prepregnancy retains the ability to mediate protection during pregnancy, when systemic levels of several hormones with putative immunomodulatory functions are increased, is unknown. Here, using murine adoptive transfer systems and a translationally relevant model of cold-adapted live-attenuated influenza A virus vaccination, we show that preexisting virus-specific memory T cell responses are largely unaltered and highly protective against heterotypic viral challenges during pregnancy.
View Article and Find Full Text PDFAm J Occup Ther
January 2025
Henry C. Hrdlicka, PhD, is Director of Research, Milne Institute for Healthcare Innovation, Gaylord Specialty Healthcare, Wallingford, CT;
Importance: No single cognitive screen adequately captures the cognitive domains needed for inpatient occupational therapy treatment planning.
Objective: To assess the construct validity of the Gaylord Occupational Therapy Cognitive (GOT-Cog©) screen, a novel comprehensive cognitive screen that evaluates functional cognition.
Design: Randomized crossover controlled study design using the St.
Public Health Nutr
January 2025
Universite Joseph KI ZERBO, Burkina Faso.
Objective: The creation of a healthy food environment is highly dependent on the policies that governments choose to implement. The objective of this study is to compare the level of implementation of current public policies aimed at creating healthy food environments in Burkina Faso with international good practice indicators.
Design: This evaluation was carried out using the Food-EPI tool.
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