Sugammadex Is Not a Silver Bullet: Caveats Regarding Unmonitored Reversal.

Anesthesiology

Retired from the Department of Anesthesiology, Weill Cornell Medical College, New York, New York.

Published: July 2023

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http://dx.doi.org/10.1097/ALN.0000000000004587DOI Listing

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Aiming toward a novel, noninvasive technique, with a real-time potential application in the monitoring of the complexation of steroidal neuromuscular blocker drugs Vecuronium () and Rocuronium () with sugammadex (, medication for the reversal of neuromuscular blockade induced by or in general anesthesia), we developed proof-of-principle methodology based on surface-enhanced Raman spectroscopy (SERS). Silver nanoparticles prepared by the reduction of silver ions with hydroxylamine hydrochloride were used as SERS-active substrates, additionally aggregated with calcium nitrate as needed. The and SERS spectra were obtained within the biorelevant 5 × 10-1 × 10 M range, as well as the SERS of , though the latter was observed only in the presence of the aggregating agent.

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