AI Article Synopsis
- Trifluoromethoxylated compounds are of significant interest, but creating efficient reagents for their synthesis is challenging.
- DNTFB (2,4-dinitro-trifluoromethoxybenzene) is introduced as a reagent for trifluoromethoxylation, enabling nucleophilic substitution without the need for metals.
- A mechanistic study identified and proposed just three reaction conditions tailored to the reactivity of different starting materials, streamlining the synthesis process.
Article Abstract
Among the general interest in fluorinated compounds, trifluoromethoxylated molecules play a specific role. However, despite this interest, the development of efficient reagents to perform trifluoromethoxylation reactions remains a challenge. Here, 2,4-dinitro-trifluoromethoxybenzene (DNTFB) is used as a trifluoromethoxylating reagent to perform nucleophilic substitution under mild metal-free conditions with different leaving groups, including direct dehydroxytrifluoromethoxylation. A mechanistic study rationalized the reaction and subsequently proposed only three reaction conditions, depending on the reactivity of the starting substrates.
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| http://dx.doi.org/10.1002/chem.202301513 | DOI Listing |
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