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Engineered extracellular vesicles for combinatorial TNBC therapy: SR-SIM-guided design achieves substantial drug dosage reduction.
Mol Ther
December 2024
Center for RNA Nanobiotechnology and Nanomedicine, College of Pharmacy and Comprehensive Cancer Center. The Ohio State University, Columbus, OH 43210, USA. Electronic address:
Article Synopsis
- Triple-negative breast cancer (TNBC) is a challenging type of breast cancer without specific treatment targets, primarily relying on traditional chemotherapy methods, making it essential to explore new therapeutic strategies.
- Researchers engineered extracellular vesicles (EVs) using RNA nanotechnology to deliver targeted therapies specifically to TNBC cells by optimizing them with survivin small interfering RNA (siRNA) and CD44 aptamer ligands.
- The study found that these engineered EVs dramatically reduced the required doses of chemotherapy drugs like gemcitabine and paclitaxel, showing effective tumor growth inhibition while potentially minimizing side effects associated with standard chemotherapy treatments.
SMIM1 absence is associated with reduced energy expenditure and excess weight.
Med
September 2024
Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK; British Heart Foundation, Cambridge Centre for Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK; Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Faculty of Health and Life Sciences RILD Building, Barrack Road, Exeter, UK. Electronic address:
Background: Obesity rates have nearly tripled in the past 50 years, and by 2030 more than 1 billion individuals worldwide are projected to be obese. This creates a significant economic strain due to the associated non-communicable diseases. The root cause is an energy expenditure imbalance, owing to an interplay of lifestyle, environmental, and genetic factors.
View Article and Find Full Text PDFModeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids.
Cell Stem Cell
June 2024
Center for Stem Cell and Organoid Medicine, Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address:
Article Synopsis
- - The human blood-brain barrier (hBBB) is crucial for regulating what enters the central nervous system, but there are currently no effective in vitro models to study it.
- - Researchers created hBBB assembloids using human stem cell-derived brain and blood vessel organoids, successfully capturing key features and communication mechanisms of the hBBB.
- - These assembloids were used to model cerebral cavernous malformations (CCMs), revealing similar structural and molecular characteristics to actual patient tissues, which may help in understanding the causes of CCMs.
Clinical practice guidelines for prevention and treatment of postoperative gastrointestinal disorder with Integrated Traditional Chinese and Western Medicine (2023).
J Evid Based Med
March 2024
Center for Evidence-Based Medicine, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Postoperative gastrointestinal disorder (POGD) was a common complication after surgery under anesthesia. Strategies in combination with Traditional Chinese Medicine and Western medicine showed some distinct effects but standardized clinical practice guidelines were not available. Thus, a multidisciplinary expert team from various professional bodies including the Perioperative and Anesthesia Professional Committees of the Chinese Association of Integrative Medicine (CAIM), jointly with Gansu Province Clinical Research Center of Integrative Anesthesiology/Anesthesia and Pain Medical Center of Gansu Provincial Hospital of Traditional Chinese Medicine and WHO Collaborating Center for Guideline Implementation and Knowledge Translation/Chinese Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) Center/Gansu Provincial Center for Medical Guideline Industry Technology/Evidence-based Medicine Center of Lanzhou University, was established to develop evidence-based guidelines.
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