AI Article Synopsis
- Tumours exist in a complex immune environment that can either help or hinder their growth, challenging the idea that all tumours share a single immune profile needing treatment.
- Recent research has shown that there are multiple immune states surrounding tumours, with around 12 major 'dominant' immune archetypes that recur across different cancers.
- Understanding these archetypal TMEs can reveal specific weaknesses that could be targeted for cancer therapies, while also anticipating potential side effects for patients.
Article Abstract
Tumours are surrounded by a host immune system that can suppress or promote tumour growth. The tumour microenvironment (TME) has often been framed as a singular entity, suggesting a single type of immune state that is defective and in need of therapeutic intervention. By contrast, the past few years have highlighted a plurality of immune states that can surround tumours. In this Perspective, we suggest that different TMEs have 'archetypal' qualities across all cancers - characteristic and repeating collections of cells and gene-expression profiles at the level of the bulk tumour. We discuss many studies that together support a view that tumours typically draw from a finite number (around 12) of 'dominant' immune archetypes. In considering the likely evolutionary origin and roles of these archetypes, their associated TMEs can be predicted to have specific vulnerabilities that can be leveraged as targets for cancer treatment with expected and addressable adverse effects for patients.
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| http://dx.doi.org/10.1038/s41568-023-00578-2 | DOI Listing |
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