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Association between marital status and all-cause mortality of patients with metastatic breast cancer: a population-based study. | LitMetric

Association between marital status and all-cause mortality of patients with metastatic breast cancer: a population-based study.

Sci Rep

Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.

Published: June 2023

AI Article Synopsis

  • The study examined the relationship between marital status and survival outcomes in patients with metastatic breast cancer (MBC) using data from the SEER database, involving 16,513 patients classified as either married or unmarried.
  • Results indicated that married patients were generally younger, received more aggressive treatment, and had better survival rates, with higher 5-year breast cancer-specific survival (42.64% vs. 33.17%) and overall survival (32.22% vs. 21.44%) compared to unmarried patients.
  • The analysis showed that marital status independently affects survival outcomes, with unmarried patients having significantly increased risks of mortality: 15.5% higher for breast cancer-specific and 19% higher for overall mortality compared to

Article Abstract

This study aimed to investigate the association between marital status and the prognosis of patients with metastatic breast cancer (MBC). Data of patients with MBC were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were classified into married and unmarried groups. Kaplan-Meier analysis with the log-rank test was conducted to compare breast cancer-specific survival (BCSS) and overall survival (OS) between the groups. Univariable and multivariable Cox proportional models were used to determine whether marital status was independently associated with OS, and the Fine-Gray subdistribution hazard method was performed to determine whether marital status was independently associated with BCSS. In total, 16,513 patients with MBC were identified, including 8949 married (54.19%) and 7564 unmarried (45.81%) patients. The married patients were significantly younger [median age (interquartile range), 59.0 (50.0-68.0) vs. 63.0 (53.0-75.0); p < 0.001] and received more aggressive treatments, such as chemotherapy (p < 0.001) and surgery (p < 0.001), than the unmarried patients. Moreover, married patients had higher 5-year BCSS (42.64% vs. 33.17%, p < 0.0001) and OS (32.22% vs. 21.44%, p < 0.0001) rates. Multivariable analysis revealed that marital status was an independent prognostic factor, and married status was associated with a significant reduction in the risk of breast cancer-specific (sub-hazard ratio, 0.845; 95% confidence interval, 0.804-0.888; p < 0.001) and all-cause (hazard ratio, 0.810; 95% confidence interval, 0.777-0.844; p < 0.001) mortality. Unmarried patients had a 15.5% increased risk of breast cancer-specific mortality and a 19.0% increased risk of overall mortality compared with married patients with MBC. BCSS and OS were superior in married populations compared with unmarried populations in most subgroups. Marital status was an independent prognostic indicator for survival in patients with MBC and was associated with significant survival benefits.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241782PMC
http://dx.doi.org/10.1038/s41598-023-36139-8DOI Listing

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