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Impact of locally delivered diphosphonates on dental implants: A systematic review and meta-analysis. | LitMetric

Impact of locally delivered diphosphonates on dental implants: A systematic review and meta-analysis.

J Stomatol Oral Maxillofac Surg

The Center of Stomatology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China. Electronic address:

Published: December 2023

AI Article Synopsis

  • - This systematic review and meta-analysis examined the impact of locally delivered diphosphonates on dental implant integration in humans, focusing on partially edentulous patients.
  • - Out of 752 identified studies, only 7 met the inclusion criteria, showing diphosphonates led to significant marginal bone loss during the pre-loading period and after one year but did not affect implant survival rates.
  • - The findings indicate that while diphosphonates may reduce marginal bone loss and enhance osseointegration, further research is needed to standardize methods and address biases for clearer conclusions.

Article Abstract

Introduction: Dental implants are a common solution for edentulous patients. This systematic review and meta-analysis aimed to determine whether locally delivered diphosphonates influence the osseointegration of dental implants in humans.

Material & Methods: In March 2023, we conducted an electronic systematic literature search using three databases (MEDLINE/PubMed, Embase, Web of Science). We included randomized trials documenting locally delivered diphosphonates in partly edentulous patients. Two independent reviewers evaluated study eligibility, extracted data, and assessed study quality.

Results: We have identified 752 studies, out of which 7 studies involving 154 patients met the inclusion criteria. The overall meta-analysis indicates that diphosphonates are associated with marginal bone loss during the pre-loading period (mean difference (MD) of -0.18 mm, 95% CI -0.24 to -0.12, p<0.00001; I²=83%), marginal bone loss after one year (MD -0.35 mm, 95% CI -0.56 to -0.14, p = 0.0009; I²=14%), and five years loading (MD -0.34 mm, 95% CI -0.56 to -0.13, p = 0.002; I²=0%). However, the drug did not seem to affect the implant survival rate (risk ratios (RR) of 1.02, 95% CI 0.98 to 1.08, P = 0.33; I²=9%).

Discussion: This study suggests that local use of diphosphonates does not affect implant survival, but it does reduce marginal bone loss and improve the osseointegration of dental implants in humans. However, future research must be more standardized and address methodological biases to draw more conclusive findings.

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Source
http://dx.doi.org/10.1016/j.jormas.2023.101521DOI Listing

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