[The phenomenon of awakening from sleep and underlying neurophysiological and autonomic mechanisms].

Current research has shown that sleep is not a global process evenly covering the entire brain. The heterogeneity of wakefulness levels in different parts of the brain and differences in their activation thresholds are especially pronounced during the transitions between sleep and wakefulness. During awakening, subcortical brain structures activate first, followed by sensory and motor cortical regions, whereas the associative cortex wakes up much later. Awakening, unlike falling asleep, is not a smooth process. It begins with a short-term sharp activation of the autonomic nervous system and some wake-promoting brain regions. The amplitude of this activity burst is out of proportion to obvious physiological needs and exceeds that observed in later periods of quiet wakefulness. The review discusses the similarities and differences between awakening from sleep and hibernation in hibernating rodents. Data on some clinical consequences of impaired awakening mechanisms are also provided.