AI Article Synopsis
- * Analyzing data from 92,795 participants over 13 years, the research finds that ideal CVH significantly reduces the risk of both developing CVD events and premature mortality.
- * Results indicate that individuals with ideal CVH can expect to live several years longer without CVDs, highlighting the importance of improving CVH as a strategy for extending healthy life and reducing healthcare costs.
Article Abstract
Objectives: Whether cardiovascular health (CVH) metrics impact longevity with and without cardiovascular diseases (CVDs) has not been well established. This study aimed to investigate the association between CVH metrics and life expectancy in participants free of CVD events. We hypothesized that ideal CVH status was associated with increased life expectancy and assessed the effect of CVH status as a prevention target of longevity in the framework of predictive, preventive, and personalized medicine (PPPM/3PM).
Methods: A total of 92,795 participants in the Kailuan study were examined and thereafter followed up until 2020. We considered three transitions (from non-CVD events to incident CVD events, from non-CVD events to mortality, and from CVD events to mortality). The multistate lifetable method was applied to estimate the life expectancy.
Results: During a median follow-up of 13 years, 12,541 (13.51%) deaths occurred. Compared with poor CVH, ideal CVH attenuated the risk of incident CVD events and mortality without CVD events by approximately 58% and 27%, respectively. Women with ideal CVH at age 35 had a 5.00 (3.23-6.77) year longer life expectancy free of CVD events than did women with poor CVH metrics. Among men, ideal CVH was associated with a 6.74 (5.55-7.93) year longer life expectancy free of CVD events.
Conclusion: An ideal CVH status is associated with a lower risk of premature mortality and a longer life expectancy, either in the general population or in CVD patients, which are cost-effective ways for personalized medicine of potential CVD patients. Our findings suggest that the promotion of a higher CVH score or ideal CVH status would result in reduced burdens of CVD events and extended disease-free life expectancy, which offered an accurate prediction for primary care following the concept of PPPM/3PM.
Supplementary Information: The online version contains supplementary material available at 10.1007/s13167-023-00322-8.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236055 | PMC |
| http://dx.doi.org/10.1007/s13167-023-00322-8 | DOI Listing |
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