Introduction: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death, and COPD exacerbation worsens the prognosis. Eosinophilic airway inflammation is a COPD phenotype that causes COPD exacerbation and is correlated with peripheral blood eosinophil count. We analyzed real-world data of COPD patients to assess the risk factors of COPD exacerbation focusing on blood eosinophils.
Materials And Methods: Patients with COPD who visited our hospital between January 1, 2018, and December 31, 2018, were recruited, and their background information, spirometry data, laboratory test results, and moderate-to-severe exacerbation events during the one-year follow-up period were collected from the electronic medical records and analyzed. The COPD exacerbation risk factors were assessed using univariate and multivariate logistic regression analyses.
Results: Twenty-two of 271 (8.1%) patients experienced moderate-to-severe exacerbation. Patients with exacerbation showed worse pulmonary function, and we found that a high blood eosinophil count (≥350 cells/L; =0.014), low % FEV1 (<50%; =0.002), increase in white blood cell (≥9000 cells/L; =0.039), and use of home oxygen therapy (=0.005) were risk factors for future exacerbations. We also found a strong correlation between eosinophil count cut-offs and exacerbation risk ( = 0.89, < 0.001). On the other hand, there was no relation between exacerbation risk and inhalation therapy for COPD.
Conclusion: In a real-world setting, peripheral blood eosinophil count could be a predictor of future COPD exacerbation.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234729 | PMC |
http://dx.doi.org/10.1155/2023/3302405 | DOI Listing |
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