Susceptibility patterns and virulence genotypes of affecting eradication therapy outcomes among Egyptian patients with gastroduodenal diseases.

Background: () is a significant human pathogen that is responsible for a variety of illnesses, including mucosa-associated lymphoid tissue lymphoma, gastric cancer, peptic ulcers, and gastritis.

Aim: To investigate the frequency of infection and its resistance patterns among Egyptian patients and to determine the influence of virulence genetic determinants on the eradication success of 14-d triple therapy regimen.

Methods: infections were investigated in 72 patients with gastroduodenal complications suggestive of infection. The and genotypes of cultured strains were studied using polymerase chain reaction. The patients underwent 14 d of triple-therapy treatment. The treatment response was examined using histology and a rapid urease test 6 wk after therapy discontinuation.

Results: The intention-to-treat eradication rate was 59.2% (95%CI: 48.2%-70.3%). Rates of resistance to clarithromycin, amoxicillin, and metronidazole were 52.8%, 81.9%, and 100%, respectively. Successful eradication of was more significantly associated with s1-positive strains [adjusted odds ratio (aOR) = 0.507, 95%CI: 0.175-0.822]. A significant association was found between failed eradication rate and strains resistant to clarithromycin (aOR = 0.204, 95%CI: -0.005 to 0.412) and amoxicillin (aOR = 0.223, 95%CI: 0.026-0.537).

Conclusion: This study's low eradication rate following 14-d triple therapy is concerning and worrying. pan-resistance to metronidazole followed by the high resistance to ciprofloxacin, amoxicillin, and clarithromycin in this research is challenging and of great concern.