A three-step sequence to construct pyrroles from three components including 2,2-dimethoxyethylamine, aryl/alkyl sulfonyl chlorides and alkynes bearing electron-withdrawing groups is presented. The pyrroles are proposed to arise via a 5--trig cyclization proceeding through both oxocarbenium and -sulfonyliminium ions. This modular route allows for the variability at the -sulfonyl group, the C2 and C3 substituents for rational vectoring of the pyrrole nucleus for downstream processes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237359 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2023.154507 | DOI Listing |
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