In recent decades, several studies demonstrating various applications of carbon dots (C-dots), including metal sensing, bioimaging, pH sensing, and antimicrobial activities, have been published. Recent developments have shifted this trend toward biomedical applications that target various biomarkers relevant to chronic diseases. However, relevant developments and research results regarding the anti-inflammatory properties of C-dots against inflammation-associated diseases have not been systematically reviewed. Hence, this review discusses the anti-inflammatory effects of C-dots in and models of LPS-induced inflammation, gout, cartilage tissue engineering, drug-induced inflammation, spinal cord injury, wound healing, liver diseases, stomach cancer, gastric ulcers, acute kidney and lung injury, psoriasis, fever or hypothermia, and bone tissue regeneration. The compiled studies demonstrate the promising potential of C-dots as anti-inflammatory agents for the development of new drugs.
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http://dx.doi.org/10.1155/2023/3076119 | DOI Listing |
ACS Nano
January 2025
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Aqueous zinc-ion batteries promise low-cost and safe grid storage, but their practical application is hindered by poor Zn anode reversibility, primarily due to dendrite formation and water-induced side reactions in the electric double layer (EDL) structure. Herein, a monolayer of hydrophobic carbon dots (CDs) was dynamically constructed at the electrode/electrolyte interface. The trace-added hydrophobic CDs in the electrolyte reconstruct a hydrophobic and favorable EDL structure, suppressing water-induced side reactions in the inner Helmholtz layer and facilitating the desolvation of hydrated zinc ions at the outer Helmholtz layer.
View Article and Find Full Text PDFFront Cell Infect Microbiol
January 2025
Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health, College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, China.
This study aimed to prepare carbon dots (GF-CDs) and examine their efficacy in mitigating oxidative stress and apoptosis in intestinal porcine epithelial cells from the jejunum (IPEC-J2 cells) induced by lipopolysaccharide (LPS). The GF-CDs were synthesized using a one-step hydrothermal method. The oxidative damage model of IPEC-J2 cells was induced through LPS treatment.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Department of Chemistry, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, 127 Youyi Road, Xi'an 710072, China. Electronic address:
β-Amyloid (Aβ) protein deposition, oxidative stress, and metal ion imbalance are established pathological features of Alzheimer's disease (AD), highlighting the imperative to efficiently reduce Aβ aggregates formation, alleviate oxidative stress, and chelate metal ions. Existing research indicates the necessity of developing multifunctional nanomaterials to facilitate multi-target therapy. In this work, we designed and prepared multifunctional selenium-doped carbonized polymer dots (SeCDs), and examined the multifunctionality at inhibiting Aβ, cleaning reactive oxygen species (ROS), and modulating copper ions.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
December 2024
College of Chemical Engineering, Hubei University of Arts and Science, Xiangyang 441053, Hubei Province, PR China; Hubei Longzhong Laboratory, Xiangyang 441000, Hubei, PR China. Electronic address:
The rapeseed meal, a type of residual by-product of rapeseed oil production was used as the precursor to prepare nitrogen self-doping carbon dots RM-CDs through an easy hydrothermal process. Thanks to the introduction of nitrogen element and oxygen-containing functional groups, RM-CDs had a fluorescence quantum yield of 18.6 %.
View Article and Find Full Text PDFInt J Nanomedicine
January 2025
Key Laboratory of Medical Cell Biology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, People's Republic of China.
Introduction: The anti-cancer properties of zinc oxide-doped carbon dots (CDs/ZnO) in inhibiting triple-negative breast cancer (TNBC) progression merit more investigation.
Methods: With citric acid as the carbon source, urea applied as the nitrogen source, and zinc oxide (ZnO) used as a reactive dopant, CDs/ZnO were synthesized by microwave heating in the current study, followed by the characterization and biocompatibility assessments. Subsequently, the anti-cancer capabilities of CDs/ZnO against TNBC progression were evaluated by various biochemical and molecular techniques, including viability, proliferation, migration, invasion, adhesion, clonogenicity, cell cycle distribution, apoptosis, redox homeostasis, metabolome, and transcriptome assays of MDA-MB-231 cells.
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