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Phase I/II results of ceralasertib as monotherapy or in combination with acalabrutinib in high-risk relapsed/refractory chronic lymphocytic leukemia. | LitMetric

AI Article Synopsis

  • * Conducted as a nonrandomized phase I/II trial, the study involved 11 patients, with different treatment regimens in two arms: ceralasertib alone or combined with acalabrutinib.
  • * Results showed significant adverse effects in the ceralasertib monotherapy group, including high rates of anemia and thrombocytopenia, while the combination therapy displayed better outcomes with a 100% response rate and no severe toxic

Article Abstract

Background: Patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) have limited treatment options. Ceralasertib, a selective ataxia telangiectasia and Rad-3-related protein (ATR) inhibitor, demonstrated synergistic preclinical activity with a Bruton tyrosine kinase (BTK) inhibitor in - and -defective CLL cells. Acalabrutinib is a selective BTK inhibitor approved for treatment of CLL.

Objectives: To evaluate ceralasertib ± acalabrutinib in R/R CLL.

Design: Nonrandomized, open-label phase I/II study.

Methods: In arm A, patients received ceralasertib monotherapy 160 mg twice daily (BID) continuously (cohort 1) or 2 weeks on/2 weeks off (cohort 2). In arm B, patients received acalabrutinib 100 mg BID continuously (cycle 1), followed by combination treatment with ceralasertib 160 mg BID 1 week on/3 weeks off from cycle 2. Co-primary objectives were safety and pharmacokinetics. Efficacy was a secondary objective.

Results: Eleven patients were treated [arm A,  = 8 (cohort 1,  = 5; cohort 2,  = 3); arm B,  = 3 (acalabrutinib plus ceralasertib,  = 2; acalabrutinib only,  = 1)]. Median duration of exposure was 3.5 and 7.2 months for ceralasertib in arms A and B, respectively, and 15.9 months for acalabrutinib in arm B. Most common grade ⩾3 treatment-emergent adverse events (TEAEs) in arm A were anemia (75%) and thrombocytopenia (63%), with four dose-limiting toxicities (DLTs) of grade 4 thrombocytopenia. No grade ⩾3 TEAEs or DLTs occurred in arm B. Ceralasertib plasma concentrations were similar when administered as monotherapy or in combination. At median follow-up of 15.1 months in arm A, no responses were observed, median progression-free survival (PFS) was 3.8 months, and median overall survival (OS) was 16.9 months. At median follow-up of 17.2 months in arm B, overall response rate was 100%, and median PFS and OS were not reached.

Conclusion: Ceralasertib alone showed limited clinical benefit. Acalabrutinib plus ceralasertib was tolerable with preliminary activity in patients with R/R CLL, though findings are inconclusive due to small sample size.

Registration: NCT03328273.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233611PMC
http://dx.doi.org/10.1177/20406207231173489DOI Listing

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