To describe the stability of nafamostat in infusion solutions, during blood sample collection and in extracted plasma samples in the autosampler. Nafamostat infusion solutions were stored at room temperature in the light for 24 h. For sample collection stability, fresh blood spiked with nafamostat was subjected to combinations of anticoagulants, added esterase inhibitor and temperature. Nafamostat was monitored in the extracted plasma samples in the autosampler. Nafamostat was stable in infusion solutions. Nafamostat in whole blood was stable for 3 h before centrifugation when collected in sodium fluoride/potassium oxalate tubes (4°C). Nafamostat in extracted plasma samples degraded at 4.7 ± 0.7% per h. Viable samples can be obtained using blood collection tubes with sodium fluoride, chilling and processing promptly.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4155/bio-2023-0040 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Fabrication Strategy for Durable Slippery Organic Coating toward Antifouling and Anticorrosion via Digital Light Processing.
ACS Appl Mater Interfaces
January 2025
Corrosion and Protection Center, Northeastern University, Shenyang 110819, PR China.
The slippery liquid-infused porous surfaces (SLIPS) have recently attracted significant interest in marine antifouling and corrosion protection. Nevertheless, the insufficient durability and corrosion resistance of SLIPS considerably affect their application potential. In this work, a preparation strategy for ultradurable slippery organic coating was proposed to combat biofouling and corrosion.
View Article and Find Full Text PDFSubcutaneous Administration of Therapeutic Monoclonal Antibody Drug Products Using a Syringe in Blinded Clinical Trials: Advances and Key Aspects Related to Blinding/Matching/Masking Strategies for Placebo Formulation.
Mol Pharm
January 2025
Drug Product Development-Steriles, Medicine Development and Supply, GSK, 1250 S. Collegeville Road, Collegeville, Pennsylvania 19426, United States.
Therapeutic monoclonal antibody (mAb) drug products are increasingly used to treat both chronic and acute diseases. These mAb drug products are often developed for subcutaneous (SC) injection to simplify dosing compared with intravenous (IV) infusion. For SC injection, the mAb liquid drug product is typically filled in a vial for use with a syringe or in a prefilled syringe, which can then be assembled into a safety syringe device or an autoinjector for direct administration.
View Article and Find Full Text PDFLemon Juice-Infused PVA Nanofibers for the Development of Sustainable Antioxidant and Antibacterial Electrospun Hydrogel Biomaterials.
Biomacromolecules
January 2025
Department of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, 02-106 Warsaw, Poland.
Cross-linking bonds adjacent polymer chains into a three-dimensional network. Cross-linked poly(vinyl alcohol) (PVA) turns into a hydrogel, insoluble structure exhibiting outstanding sorption properties. As an electrospinnable polymer, PVA enables the creation of nanofibrous hydrogels resembling biological tissues, thus ideal for nature-inspired platforms.
View Article and Find Full Text PDFEvaluation of chitosan/diosgenin-infused manganese dioxide nanocomposite for highly effective photocatalytic and antibacterial activity.
Int J Biol Macromol
December 2024
Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 602105, Tamil Nadu, India.
Article Synopsis
- The MnO/Dio@CS nanocomposite was studied for its ability to break down organic dyes Acid Green and Malachite Green Oxalate under visible light, achieving over 85% degradation in just 60 minutes.
- The nanocomposite exhibited superior photocatalytic performance compared to pure MnO nanoparticles and was characterized using advanced techniques like FESEM and UV-vis spectroscopy.
- Additionally, it demonstrated significant antibacterial properties against Bacillus subtilis and Pseudomonas aeruginosa, indicating its potential as a dual-functional material for environmental applications.
Elimination of High-grade Gliomas Through Induced Cytolysis, Elucidated by Two Patient Cases.
Anticancer Res
January 2025
Department of Medical Sciences, Clinical Chemistry, University of Uppsala, Uppsala, Sweden
Background/aim: Glioblastoma multiforme (GBM) is the most common and aggressive form of primary malignant tumors in the central nervous system of adults. In practice, all patients with GBM experience relapse, and treatment options become limited following first-line therapy. We previously reported a new, successful treatment approach for a GBM patient, implemented in direct conjunction with surgical intervention.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!