AI Article Synopsis
- Rapid and accurate diagnosis is crucial for effective treatment of multiple sclerosis (MS), a chronic and neurodegenerative disease of the central nervous system.
- Traditional methods like clinical observation and MRI for diagnosing MS are often lengthy, highlighting the need for faster alternatives.
- This study explores the use of Raman spectroscopy alongside chemometric analysis, suggesting it could serve as a new diagnostic tool by identifying specific lipids and carotenoid molecules, potentially improving the speed and accuracy of MS diagnosis.
Article Abstract
Rapid and accurate diagnosis of any illness determines the success of treatment. The same applies to multiple sclerosis (MS), chronic, inflammatory, and neurodegenerative diseases (ND) of the central nervous system (CNS). Unfortunately, the definitive diagnosis of MS is prolonged and involves mainly clinical symptoms observation and magnetic resonance imaging (MRI) of the CNS. However, as we previously reported, Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy shed new light on the minimally invasive, label-free, and rapid diagnosis of this illness through blood fraction. Herein we introduce Raman spectroscopy coupled with chemometric analysis to provide more detailed information about the biochemical changes behind MS. This pilot study demonstrates that mentioned combination may provide a new diagnostic biomarker and bring closer to rapid MS diagnosis. It has been shown that Raman spectroscopy provides lipid and carotenoid molecules as useful biomarkers which may be applied for both diagnosis and treatment monitoring.
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| http://dx.doi.org/10.1016/j.bbagen.2023.130395 | DOI Listing |
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