Prolactin-releasing peptide (PrRP) has been investigated as a potential therapeutic for diabetes by the effect of food intake reduction, increasing leptin signaling, and insulin tolerance. Recent studies focused on its synaptogenesis and protective effects against neurodegeneration. Whereas 1,2-diacetylbenzene (DAB), a common metabolite of a neurotoxicant 1,2-diethyl benzene, causes memory impairment and neurotoxicity partly through the inflammatory process. Our present study assessed the effect of PrRP in microglia and its action in balancing the inflammation to protect against DAB. We observed that PrRP modulated NADPH oxidase - regulated NLRP3 inflammasome and PRL signaling pathways differently between physical and toxic conditions in microglia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.npep.2023.102349 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effectiveness and safety of aripiprazole oral solution in the acute treatment of schizophrenia in Chinese patients.
BMC Psychiatry
December 2024
The National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
Background: This study investigates the effectiveness and safety of aripiprazole oral solution in Chinese patients with schizophrenia.
Methods: This was a multicenter, single-arm phase IV study involving 134 patients in China in the acute stage of schizophrenia from May 2021 to July 2022. The patients received aripiprazole oral solution 10 - 30 mg/d for 12 weeks.
Productive, Reproductive, Behavioural, Gene Expression, Histological, and Economic Criteria of Feeding Fenugreek and Berseem Seeds as Alternative Protein Sources in New Zealand White Does Rabbits (Oryctolagus Cuniculus).
J Anim Physiol Anim Nutr (Berl)
December 2024
Veterinary Economics and Farm Management, Department of Animal Wealth Development, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.
Feed cost represents about 70% of the total production costs of rabbit farms. There is little research on the usage of Berseem and Fenugreek seeds as substitutes for soybeans in rabbit diets. The current investigation was conducted to assess the influence of dietary inclusion of Fenugreek and/or Berseem seeds at varying levels as a substitute for soybean meal on reproductive performance, milk production, maternal behaviour, economic efficiency, mammary gland and ovarian histology, and relative expression of reproductive genes of New Zealand White rabbit does.
View Article and Find Full Text PDFA correlation study between cervical cancer and sex hormones.
Front Oncol
November 2024
Health Management Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Objective: The aims of this study were to investigate the association between positive TCT and sex hormone levels and to evaluate the feasibility of change in sex hormone level as a potential predictor of cervical cancer.
Methods: We recruited 910 female participants from the health examination center of a hospital in Guizhou between 2019 and 2023. All participants had undergone both hematologic examinations and cervical cancer screening.
Radio-protective effects of melatonin therapy against testicular oxidative stress: a systematic review and meta-analysis of rodent models.
Ann Med Surg (Lond)
December 2024
Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Radiation exposure is a concern in today's world, given the widespread use of electronic devices and medical procedures involving ionizing and non-ionizing radiation. Radiations may cause male infertility by inducing oxidative stress in testicular tissue. Melatonin has antioxidant properties.
View Article and Find Full Text PDFMaternal dietary olive oil protects diabetic rat offspring from impaired uterine decidualization.
Placenta
November 2024
Universidad de Buenos Aires (UBA). Facultad de Medicina, Argentina; CONICET - UBA. Laboratory of Reproduction and Metabolism, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Buenos Aires, Argentina. Electronic address:
Article Synopsis
- Maternal diabetes increases the risk of negative outcomes for both mothers and their offspring, and this study investigated whether changes in uterine decidualization in prepubertal offspring from diabetic rats could be influenced by diets including extra virgin olive oil (EVOO).
- The study involved mating control and mildly diabetic female rats with control males and analyzing their offspring after dietary regulation, focusing on key signaling pathways and microRNAs that affect uterine decidualization.
- Results indicated that offspring from diabetic mothers had disrupted signaling pathways in the uterus, but these negative effects were largely mitigated by the inclusion of EVOO in the maternal diet.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!