Building capacity for collaborative research between basic scientists and underrepresented communities in cancer research.

Cancer Causes Control

Department of Health Promotion Sciences, Mel & Enid Zuckerman College of Public Health, University of Arizona, 1295 N Martin Avenue, Tucson, AZ, 85724, USA.

Published: October 2023

Purpose: Basic science research is critical for understanding biological mechanisms essential to advances in cancer prevention, diagnoses and treatment. However, most of this research is conducted outside of the purview of community observation or input, leaving these research processes mysterious and subsequent findings disconnected from the communities they intend to benefit. This paper discusses strategies to build capacity for collaborations between basic scientists and Hispanic community members at the University of Arizona Cancer Center (UACC).

Methods: Through partnership of the Cancer Biology Program and Office of Community Outreach and Engagement both at UACC, the Research Outreach for Southern Arizona (ROSA) program was developed as a way to forward the following strategies to build capacity for collaboration: forming a community working group, launching a community and student ambassador program, hosting scientific cafés and developing a community-based survey.

Results: The strategies underpinning the ROSA program have been integral in bridging dialogue between basic scientists and the community and fostering bidirectional learning opportunities. Each of the strategies presented have documented successes and based on the lessons learned, they have evolved into productive and integral parts of UACC's overall strategy of bridging scientific research and communities.

Conclusion: While the strategies discussed are evolving, they help foster dialogue and exchange between basic scientists and community members that demystifies basic science research and facilitates culturally tailored approaches to address health disparities of vulnerable communities. These strategies also have the potential to shift cancer research into a paradigm that is more collaborative and transformative.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239042PMC
http://dx.doi.org/10.1007/s10552-023-01726-7DOI Listing

Publication Analysis

Top Keywords

basic scientists
16
basic science
8
strategies build
8
build capacity
8
community members
8
rosa program
8
scientists community
8
community
7
basic
6
strategies
6

Similar Publications

Nanomaterials-Induced Pyroptosis: Advancing Novel Therapeutic Pathways in Nanomedicine.

Small Methods

January 2025

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), Beijing, 100190, China.

Pyroptosis, a form of programmed cell death characterized by cell lysis and inflammation, has significant implications for disease treatment. Nanomaterials (NMs), with their unique physicochemical properties, can precisely modulate pyroptosis, offering novel and intelligent therapeutic strategies for cancer, infectious diseases, and chronic inflammatory conditions with targeted activation and reduced systemic toxicity. This review explores the mechanisms by which NMs regulate pyroptosis, comparing molecular and NM inducers, and examines the role of intrinsic properties such as size, shape, surface charge, and chemical composition in these processes.

View Article and Find Full Text PDF

Mid-Infrared High-Power InGaAsSb/AlGaInAsSb Multiple-Quantum-Well Laser Diodes Around 2.9 μm.

Nanomaterials (Basel)

January 2025

Key Laboratory of Optoelectronic Materials and Devices, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China.

Antimonide laser diodes, with their high performance above room temperature, exhibit significant potential for widespread applications in the mid-infrared spectral region. However, the laser's performance significantly degrades as the emission wavelength increases, primarily due to severe quantum-well hole leakage and significant non-radiative recombination. In this paper, we put up an active region with a high valence band offset and excellent crystalline quality with high luminescence to improve the laser's performance.

View Article and Find Full Text PDF

Deletion of bZIP Transcription Factor Reveals Specialized Metabolites Potentially Regulating Stress Response in .

J Fungi (Basel)

January 2025

State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Fungal secondary metabolism (SM) is highly correlated with physiological processes that are typically regulated by pleiotropic regulators. In this study, we purposefully altered , a crucial regulator associated with oxidative stress in CGMCC 3.1066.

View Article and Find Full Text PDF

Maize () is India's third-largest grain crop, serving as a primary food source for at least 30% of the population and sustaining 900 million impoverished people globally. The growing human population has led to an increasing demand for maize grains. However, maize cultivation faces significant challenges due to a variety of environmental factors, including both biotic and abiotic stresses.

View Article and Find Full Text PDF

Background: To elucidate the genetic and molecular mechanisms underlying psoriasis by employing an integrative multi-omics approach, using summary-data-based Mendelian randomization (SMR) to infer causal relationships among DNA methylation, gene expression, and protein levels in relation to psoriasis risk.

Methods: We conducted SMR analyses integrating genome-wide association study (GWAS) summary statistics with methylation quantitative trait loci (mQTL), expression quantitative trait loci (eQTL), and protein quantitative trait loci (pQTL) data. Publicly available datasets were utilized, including psoriasis GWAS data from the European Molecular Biology Laboratory-European Bioinformatics Institute and the UK Biobank.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!