Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41579-023-00921-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Use of Claims to Assess Outcomes and Treatment Effects in the Evolut Low Risk Trial.
Circ Cardiovasc Interv
January 2025
Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA (C.L., A.T., Y.S., J.S., R.W.Y.).
Background: Food and Drug Administration-mandated postmarket studies for transcatheter aortic valve replacement in low-risk populations plan to use passively collected registry data linked to claims for long-term follow-up out to 10 years. Therefore, it is critically important to understand the validity of these claims-based end points. We sought to evaluate the ability of administrative claims with () codes to identify trial-adjudicated end points and reproduce treatment comparisons of aortic valve replacement in the Evolut Low Risk Trial.
View Article and Find Full Text PDFGuillain-Barré Syndrome Following Laparoscopic Sleeve Gastrectomy: A Tale of Two Cases.
Obes Surg
January 2025
Arab Women's Union Hospital, Nablus, Occupied Palestinian Territories.
Obesity management through laparoscopic sleeve gastrectomy can occasionally lead to rare but severe complications, including Guillain-Barré Syndrome (GBS). This report analyzes two cases of GBS following LSG, highlighting differences in symptoms, diagnosis, and management. The first patient experienced rapid onset neurological symptoms post-surgery, confirmed as GBS through clinical and electrophysiological assessments, and responded well to intravenous immunoglobulin.
View Article and Find Full Text PDFIdentification of Gene Regulatory Networks in B-Cell Progenitor Differentiation and Leukemia.
Genes (Basel)
July 2024
Department of Human and Animal Cell Lines, Leibniz-Institute DSMZ, 38124 Braunschweig, Germany.
Pro-B- and pre-B-cells are consecutive entities in early B-cell development, representing cells of origin for B-cell precursor acute lymphoid leukemia (BCP-ALL). Normal B-cell differentiation is critically regulated by specific transcription factors (TFs). Accordingly, TF-encoding genes are frequently deregulated or mutated in BCP-ALL.
View Article and Find Full Text PDFpiR-823 tale as emerging cancer-hallmark molecular marker in different cancer types: a step-toward ncRNA-precision.
Naunyn Schmiedebergs Arch Pharmacol
August 2024
Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo, Abassia, 11566, Egypt.
PIWI-interacting RNAs (piRNAs) have received a lot of attention for their functions in cancer research. This class of short non-coding RNAs (ncRNA) has roles in genomic stability, chromatin remodeling, messenger RNA (mRNA) integrity, and genome structure. We summarized the mechanisms underlying the biogenesis and regulatory molecular functions of piRNAs.
View Article and Find Full Text PDFChronic Lead Exposure in Adult Mice: Associations with miR-671/CDR1as Regulation, NF-κB Signaling, and Alzheimer's Disease-like Pathology.
Toxics
June 2024
State Key Laboratory of Trauma and Chemical Poisoning, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Article Synopsis
- * Mice were given controlled doses of lead over 10 months, and results showed that higher lead levels led to worse memory and learning abilities, illustrated by behavioral tests and brain tissue analysis.
- * Molecular analyses revealed increased levels of proteins and genes associated with Alzheimer's, along with suppressed expression of CDR1as, indicating a potential link between lead exposure and neurotoxicity that requires further research.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!