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Predictive modeling to evaluate long-term treatment effectiveness of darvadstrocel in patients with complex perianal fistulas in Crohn's disease.
BMC Gastroenterol
December 2024
Formerly Gastroenterology Department, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Hospital Clínic de Barcelona, Barcelona, Spain.
Background: Current therapies for complex Crohn's perianal fistulas (CPF) have a limited ability to achieve long-term healing. Darvadstrocel (DVS) is an expanded allogeneic adipose-derived mesenchymal stem cell therapy that has demonstrated efficacy in treating complex CPF in clinical trials. There are, however, limited long-term comparative data with standard of care (SoC).
View Article and Find Full Text PDFSpiers Memorial Lecture: New horizons in nanoelectrochemistry.
Faraday Discuss
November 2024
Department of Chemistry, Texas A&M University, College Station, TX 77843, USA.
This introductory lecture prefaces the 2024 New Horizons in Nanoelectrochemistry . A broad view of the previous Discussions related to nanoelectrochemistry is taken. Big ideas or concepts discussed at these previous meetings are identified, along with specific examples in each area.
View Article and Find Full Text PDFInnovative approaches to cardiovascular safety pharmacology assessment.
J Pharmacol Toxicol Methods
July 2024
Cardiovascular Division, King's College London, Rayne Institute, St Thomas' Hospital, London SE17EH, UK.
This editorial prefaces the annual themed issue on safety pharmacology (SP) methods which has been published since 2004 in the Journal of Pharmacological and Toxicological Methods (JPTM). Here we highlight content derived from the 2023 Safety Pharmacology Society (SPS) meeting held in Brussels, Belgium. The meeting generated 138 abstracts, reproduced in the current volume of JPTM.
View Article and Find Full Text PDFBioactive Phyto-Compounds with Antimicrobial Effects and AI: Results of a Desk Research Study.
Microorganisms
May 2024
Department of Social Medicine and Health Care Organisation, Faculty of Public Health, Medical University of Varna, 9002 Varna, Bulgaria.
Resistance of microorganisms to antibiotics represents a formidable global challenge, manifesting in intricate public health ramifications including escalated mortality rates and augmented healthcare costs. The current efforts to manage antimicrobial resistance (AMR) are limited mainly to the standard therapeutic approaches. The aim of this study is to present and analyze the role of artificial intelligence (AI) in the search for new phyto-compounds and novel interactions with antimicrobial effects.
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