In this issue of Cell Stem Cell, Beziaud et al. show that immunotherapy induces stem-like properties in models of breast cancer. Strikingly, T-cell-derived IFNγ promotes cancer stem cell (CSC) phenotypes, therapy resistance, and metastasis. Targeting BCAT1 downstream offers promise for enhancing immunotherapy outcomes.
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| http://dx.doi.org/10.1016/j.stem.2023.05.011 | DOI Listing |
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