AI Article Synopsis
- - The study aimed to compare the long-term risk of SARS-CoV-2 infection between those who gained immunity from natural infection and those who received vaccines, using a large cohort from Lombardy, Italy.
- - Researchers analyzed data from over 19,000 participants to measure the incidence of new infections over nine months, focusing on those who were either naturally immune, vaccinated, or unvaccinated.
- - Results showed that the cumulative risk of new infections after nine months was similar for both natural immunity (21.8%) and vaccine-induced immunity (22.0%), suggesting both types provide comparable protection.
Article Abstract
Objectives: To compare the long-term cumulative risk of SARS-CoV-2 infection associated with natural and vaccine-induced immunity.
Methods: Retrospective population-based cohort study based on registry of COVID-19 vaccinations and SARS-CoV-2 infections among 9.1 million citizens of Lombardy, Italy, eligible for vaccination on 27th December 2020. Those who developed SARS-CoV-2 infection from 24th May to 14th September 2021, provided they did not yet receive the COVID-19 vaccine when infection was confirmed, and those who received the second mRNA vaccine dose, provided they had not yet developed the infection, were selected to be 1:1 matched for sex, age and index date. The latter corresponded to 90 days after confirmed infection or 14 days after vaccine administration. A control cohort including citizens who, on the index date, had neither developed infection nor received vaccination was also selected. Kaplan-Meier curves were used for comparing the cumulative incidence of new SARS-CoV-2 infection from the index date until 22nd June 2022.
Results: Overall, 19,418 1:1:1 risk-sets were included. After 9 months of follow-up, the cumulative risk of new SARS-CoV-2 infection was 21.8%, 22.0%, and 25.9%, respectively, among exposed to natural immunity, vaccine-induced immunity and unexposed.
Conclusions: Equivalent potential for protecting against new SARS-CoV-2 infection was observed.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198735 | PMC |
| http://dx.doi.org/10.1016/j.jiph.2023.05.018 | DOI Listing |
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