Objectives: October of 2017 marked the opening of the first US Opioid Treatment Program (OTP) that was staffed 24 hours a day, 7 days a week, with admissions on demand, both during normal OTP working hours and outside the hours when most OTPs are able to accept new patients. This article compares demographic and treatment outcomes for those patients admitted during normal working hours with those admitted after hours or on weekends.
Methods: All admissions to the 24-hour OTP between January 2018 and December 2020 who were new to treatment at this OTP and started on methadone were included. An internal database of patient demographics and dosing events was collected during the normal treatment process. These data were examined regarding initial demographics, dosing, and treatment outcomes, comparing patients admitted during normal working hours with those admitted when most OTPs would be closed and unable to admit new patients.
Results: A total of 7,334 admissions were included, 2,631 during normal working hours, and 4,703 after hours or on weekends. After-hours patients were comparable in age but were more likely to be male (56.0% vs. 52.5%, P < 0.01), employed (24.1% vs. 22.1%, P < 0.05), and White versus non-White (56.2% vs. 51.5%, P < 0.001) compared with working-hour admissions. Outcomes of first-day dose, 30th-day dose, and 30-day treatment attendance did not differ between the 2 groups.
Conclusions: In this situation where patients could be admitted at any time, the majority presented after hours. Patients who were admitted after-hours did not have worse treatment outcomes than those who were admitted during working hours. These findings suggest that offering OTP admission after-hours and on weekends will not result in attracting patients with low motivation and poorer outcomes than those who are admitted during working hours. Extending OTP admission hours has the potential to improve medication for opioid use disorder access and treatment outcomes.
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http://dx.doi.org/10.1097/ADM.0000000000001111 | DOI Listing |
Ann Ig
March 2025
Department of Global Public Health Policy and Governance, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, India.
Background: Seafarers experience unique challenges related to their profession, including risks for mental health. The present study explored the correlates of depression among seafarers in India.
Methods: Following ethics clearance, this cross-sectional study was conducted at an international shipping company in Mumbai, India.
Int J Nanomedicine
March 2025
Department of Ultrasound, the Affiliated Hospital of Qingdao University, Qingdao, 266003, People's Republic of China.
Introduction: Triple-negative breast cancer (TNBC) is known for its high malignancy, limited clinical treatment options, and poor chemotherapy outcomes. Although some advancements have been made using nanotechnology-based chemotherapy for TNBC treatment, the controlled and on-demand release of chemotherapeutic drugs at the tumor site remains a challenge.
Methods: We manufactured DOX/BaTiO@cRGD-Lip (DBRL) nanoparticles as an ultrasound (US)-controlled release platform targeting the delivery of Doxorubicin (DOX) for TNBC treatment.
Int J Gen Med
March 2025
Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Introduction: This study aimed to explore changes in the venous return system in patients with Constrictive pericarditis (CP) after pericardial stripping and examine their value in predicting mortality.
Methods: An 8-year single-center retrospective cohort study including patients with CP after pericardial stripping surgery. Hemodynamic parameters were analyzed in 90 patients at 11 time points including before and after surgery and every 4 to 9 hours in the first 48 hours in the ICU (pre-operation, post-operation, 0h, t1, t2, t3, 24h, t4, t5, t6, 48h).
Cureus
February 2025
Department of Obstetrics and Gynaecology, NRI Institute of Medical Sciences, Visakhapatnam, IND.
Background: Caesarean delivery is an abdominal surgery and hydration and nutrition during postoperative care is a main concern for women. It is customary to give oral fluids only after 24 hours following the return of bowel sounds. Early oral fluid intake has been recommended for women after caesarean delivery, which may improve earlier gastrointestinal recovery that can facilitate early discharge from hospital.
View Article and Find Full Text PDFNIHR Open Res
January 2025
University of Plymouth School of Nursing and Midwifery, Plymouth, England, UK.
Background: During pregnancy, labour and early motherhood, most women in the UK receive care from different midwives. NHS policy change in England sought to introduce a model of care whereby each woman is cared for by the same midwife throughout antenatal, intrapartum and postnatal periods, supported by a small team of midwives to cover off-duty periods. This model is called the Midwifery Continuity of Carer (MCoC).
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