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Increased Expression of MST1 in Patients With Epilepsy and in a Rat Model of Epilepsy.
Synapse
January 2025
Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Mammalian sterile20-like kinase 1 (MST1), a serine/threonine kinase frequently expressed, has emerged as pivotal modulator of multiple physiological and pathological conditions such as cellular growth, programmed cell death, oxidative stress, neurodegeneration, inflammation, and synaptic plasticity in the central nervous system. Various neurological diseases are associated with the activation of MST1. Epilepsy is a severe neurological disorder characterized by abrupt abnormal electrical activity in the brain and recurring spontaneous seizures.
View Article and Find Full Text PDFExploring Biomarkers for Excess Extracellular Fluid in the Context of Physical Function in Chronic Kidney Disease Patients.
J Pers Med
November 2024
Division of Nephrology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13496, Republic of Korea.
: Fluid overload is an important risk factor for protein-energy wasting, which could lead to poor outcomes, such as higher morbidity and mortality, in patients with chronic kidney disease (CKD). This study aimed to validate the possible myokine as a biomarker of volume status in patients with non-dialysis CKD. : In total, 151 patients with CKD were enrolled from a single medical center.
View Article and Find Full Text PDFAnalysis of risk factors for benign central airway stenosis after COVID-19 infection.
Eur J Med Res
December 2024
Henan Institute of Interconnected Intelligent Health, Henan Key Laboratory of Chronic Disease Prevention and Therapy & Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, China.
Background: To investigate the risk factors associated with benign central airway stenosis following COVID-19 infection.
Methods: The clinical data of 235 patients hospitalized for COVID-19 infection at the First Affiliated Hospital of Zhengzhou University from October 2022 to October 2023 were retrospectively analyzed. Based on the occurrence of postoperative central airway stenosis, the patients were categorized into a stenosis group (118 cases) and a control group (117 cases).
Higher CSF sTREM2 attenuates APOE ε4-related risk for amyloid pathology in cognitively intact adults: The CABLE study.
J Neurochem
January 2025
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
The triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein found in microglia within the brain, and its soluble form (sTREM2) has been shown to reduce amyloid deposition. Whether elevated TREM2-mediated microglial activity decreases the risk of Alzheimer's disease (AD) is unclear. The aim of this study was to assess whether high cerebrospinal fluid (CSF) levels of sTREM2 attenuate the risk of APOE ε4-associated amyloid pathology.
View Article and Find Full Text PDFNOCTURNAL ENURESIS SYMPTOMS AND RISK FACTORS AMONG CHILDREN AND ADOLESCENTS IN QASSIM REGION, SAUDI ARABIA.
Georgian Med News
October 2024
Department of Surgery, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Background: Nocturnal enuresis (NE), commonly referred to as nighttime bed wetting, is a common condition characterized by involuntary urination during sleep. This condition affects a significant number of children worldwide with a higher prevalence in boys than girls aged 6-12 years old. This study aims to evaluate the symptoms, assess the risk factors and address the response to different management types of this disorder among children and adolescents living in the Qassim region, Saudi Arabia.
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