Objective: Bone morphogenetic protein 6 (BMP6) and noggin both have been implicated in the pathophysiology of chronic dementia, and chronic schizophrenia (SCZ) has high risk for progressing to dementia in later life. The current study investigated the relationship between blood BMP6/noggin levels and cognitive function in chronic SCZ elderly.
Methods: A total of 159 chronic SCZ elderly and 171 community normal controls (NC) were involved in the present study. Blood cytokines including BMP6 and its antagonist-noggin, and cognitive function were measured in all subjects, 157 subjects among them received apolipoprotein E () genotype test, and 208 subjects received cognitive assessment at 1-year follow-up.
Results: Chronic SCZ elderly had decreased levels of blood BMP6 and noggin compared to healthy controls, especially in the subgroup of chronic SCZ with dementia. Blood BMP6 combing with noggin could distinguish chronic SCZ from NC elderly. ε4 carriers had lower levels of BMP6 than non-ε4 carriers under chronic SCZ.
Conclusions: There was a significant relationship of blood BMP6/noggin with cognitive performance in chronic SCZ.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229485 | PMC |
| http://dx.doi.org/10.1007/s11571-022-09855-6 | DOI Listing |
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